A simplified model for mitochondrial ATP production
A simplified model for mitochondrial ATP production
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DOI：
10.1016/j.jtbi.2006.07.019
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发表时间：
2006-12-21
影响因子：
2
通讯作者：
Sherman, Arthur
中科院分区：
文献类型：
--
作者：
Bertram, Richard;Gram Pedersen, Morten;Sherman, Arthur
葡萄糖代谢过程中合成的三磷酸腺苷（ATP）大部分是在线粒体中通过氧化磷酸化产生的。这是一个复杂的反应，由线粒体呼吸作用产生的质子梯度通过线粒体内膜提供能量。马格努斯和凯泽早些时候建立了一个详细的反应模型，其中包括关键线粒体变量的动态方程。然而，这个模型非常复杂。我们开发了一个更简单的模型，它捕获了原始模型的行为，但更容易使用和理解。然后我们用它来研究线粒体对糖酵解和钙输入的反应。我们使用该模型来解释在低糖和高糖条件下提高细胞质Ca2+的相反作用的实验观察，并预测胰腺β细胞中线粒体酶烟酰胺核苷酸转氢酶（Nnt）突变的影响。(c) 2006 Elsevier Ltd.版权所有。
Most of the adenosine triphosphate (ATP) synthesized during glucose metabolism is produced in the mitochondria through oxidative phosphorylation. This is a complex reaction powered by the proton gradient across the mitochondrial inner membrane, which is generated by mitochondrial respiration. A detailed model of this reaction, which includes dynamic equations for the key mitochondrial variables, was developed earlier by Magnus and Keizer. However, this model is extraordinarily complicated. We develop a simpler model that captures the behavior of the original model but is easier to use and to understand. We then use it to investigate the mitochondrial responses to glycolytic and calcium input. We use the model to explain experimental observations of the opposite effects of raising cytosolic Ca2+ in low and high glucose, and to predict the effects of a mutation in the mitochondrial enzyme nicotinamide nucleotide transhydrogenase (Nnt) in pancreatic beta-cells. (c) 2006 Elsevier Ltd. All rights reserved.