Randomized trial of high nutrient density formula versus standard formula in chronic lung disease
Randomized trial of high nutrient density formula versus standard formula in chronic lung disease
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DOI：
10.1111/j.1651-2227.1997.tb08937.x
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发表时间：
1997-06-01
期刊：
影响因子：
3.8
通讯作者：
Lucas, A
中科院分区：
文献类型：
--
作者：
Fewtrell, MS;Adams, C;Lucas, A
为了检验以下假设：通过提供更浓缩的营养形式，可以改善患有慢性肺病的婴儿的营养摄入和生长，并且较低的体积可以改善呼吸状态，60 名 28 天龄需要补充氧气的早产儿被随机分配为 180 毫升/公斤/天的低密度（24 kcal/oz）配方奶粉，或 145 毫升/公斤/天的高密度（30 kcal/oz）配方奶粉。饮食组之间的生长、呼吸结果、水肿或利尿需求没有差异。喂养高营养密度配方奶粉的婴儿的总能量（143 kcal/kg/天 vs 134 kcal/kg/天）和蛋白质（3.9 vs 3.6 g/kg/天）摄入量明显更高，这主要是因为低密度配方奶粉组没有达到指定的 180 ml/kg/天。总之，尽管总能量和蛋白质摄入量略有增加，但患有慢性肺病的婴儿使用高密度配方奶粉并没有改善生长或呼吸系统结果。
To test the hypothesis that the nutrient intake and growth of infants with chronic lung disease would be improved by providing nutrients in more concentrated form, and that the lower volume would improve respiratory status, 60 preterm infants requiring supplemental oxygen at 28 days of age were randomly assigned a low-density (24 kcal/oz) formula fed at 180 ml/kg/day, or a high-density (30 kcal/oz) formula at 145 ml/kg/day. There was no difference in growth, respiratory outcome, oedema or diuretic requirement between dietary groups. Infants fed the high nutrient density formula had significantly greater total energy (143 vs 134 kcal/kg/day) and protein (3.9 vs 3.6 g/kg/day) intakes, largely because the low-density formula group did not achieve the designated 180 ml/kg/day. In conclusion, use of a high-density formula in infants with chronic lung disease did not improve growth or respiratory outcome, despite a small increase in total energy and protein intake.