Synthesis, glycosidase activity and X-ray crystallography of 3-amino-sugars
Synthesis, glycosidase activity and X-ray crystallography of 3-amino-sugars
复制标题
DOI：
10.1039/b605916c
复制
发表时间：
2006-01-01
影响因子：
3.2
通讯作者：
Jenkins, Paul R.
中科院分区：
文献类型：
--
作者：
Maxwell, Vanessa L.;Evinson, Emma L.;Jenkins, Paul R.
The cleavage of two sugar epoxides, methyl 2,3- anhydro-alpha-D-mannopyranoside and 2,3-anhydro-alpha-D-allopyranoside, with amines is presented as a method for preparing a library of 3- amino- sugars ( methyl 3- amino- 3- deoxy-alpha- D-altropyranosides and methyl 3-amino-3-deoxy-alpha-D-glucopyranosides) as potential glycosidase inhibitors. Several of the altropyranosides were micromolar inhibitors of bovine liver beta-galactosidase and almond beta-glucosidase. X-Ray crystal structures were determined for one of the methyl 3-amino-3-deoxy-alpha-D-altropyranosides, 4t, and one of the methyl 3-amino-3-deoxy-alpha-D-glucopyranosides, 6d.
