AKINESIA - A SYNDROME COMMON TO PARKINSONISM, RETARDED DEPRESSION, AND NEGATIVE SYMPTOMS OF SCHIZOPHRENIA
AKINESIA - A SYNDROME COMMON TO PARKINSONISM, RETARDED DEPRESSION, AND NEGATIVE SYMPTOMS OF SCHIZOPHRENIA
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DOI：
10.1016/0010-440x(92)90045-r
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发表时间：
1992-07-01
影响因子：
7.3
通讯作者：
SIRIS, SG
中科院分区：
文献类型：
--
作者：
BERMANZOHN, PC;SIRIS, SG
一种明显的运动功能减退综合征似乎存在于几种不同的神经精神病诊断中，包括（1）运动活动减慢，难以启动和维持行为，（2）快感缺乏伴抑郁情绪和情感范围减少，以及（3）认知障碍。具体来说，三个公认的状态帕金森综合征，抑郁症，精神分裂症的阴性症状突出的特点，这种综合征的组成部分，并减少多巴胺在大脑中的营业额已被假设在每一个的病理生理学中发挥作用。虽然这一概念化的方面仍然存在争议，但它产生了可检验的假设，可能对这些国家的理解和治疗产生影响。
A distinct hypokinetic syndrome appears to exist across several different neuropsychiatric diagnoses, involving (1) slowed motor activity with difficulty initiating and sustaining behaviors, (2) anhedonia with depressed mood and reduced affective range, and (3) cognitive impairment. Specifically, three well-recognized states—parkinsonism, retarded depression, and the negative symptoms of schizophrenia—prominently feature the components of this syndrome, and reduced dopamine turnover in the brain has been hypothesized to play a part in the pathophysiology of each. While aspects of this conceptualization remain controversial, it generates testable hypotheses that could have implications for the understanding and treatment of these states.