Eosinophils in Gastrointestinal Disorders: Eosinophilic Gastrointestinal Diseases, Celiac Disease, Inflammatory Bowel Diseases, and Parasitic Infections.
Eosinophils in Gastrointestinal Disorders: Eosinophilic Gastrointestinal Diseases, Celiac Disease, Inflammatory Bowel Diseases, and Parasitic Infections.
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DOI：
10.1016/j.iac.2015.04.003
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发表时间：
2015-08
影响因子：
2.6
通讯作者：
Furuta GT
中科院分区：
文献类型：
--
作者：
Mehta P;Furuta GT
胃肠道提供了一个有趣的器官来考虑嗜酸性粒细胞在健康和疾病中的作用。正常胃肠道（除食管外）充满嗜酸性粒细胞，嗜酸性粒细胞以不同数量存在于整个粘膜中。后一个事实提出了嗜酸性粒细胞参与先天防御机制的可能性。相比之下，许多临床研究提供了大量数据，将嗜酸性粒细胞数量增加与炎性GI疾病相关联;这些发现提示了嗜酸性粒细胞可能对肠道产生有害影响的担忧。在这篇文章中，我们提出了4个疾病的过程中，已与嗜酸性粒细胞增多症的临床特点，并建议需要调查的领域，其临床意义和科学的相关性。
The gastrointestinal tract provides an intriguing organ for considering the eosinophil’s role in health and disease. The normal gastrointestinal (GI) tract, except for the esophagus, is populated by eosinophils that are present throughout the mucosa in varying numbers. This latter fact raises the possibility that eosinophils participate in innate mechanisms of defense. In contrast, a number of clinical studies provide a wealth of data that associates increased numbers of eosinophils with inflammatory GI diseases; these findings prompt concerns that eosinophils may have a deleterious effect on the gut. In this article we present clinical features of 4 disease processes that have been associated with eosinophilia and suggest areas requiring investigation as to their clinical significance and scientific relevance.