Structure and function of the mitochondrial calcium uniporter complex.
Structure and function of the mitochondrial calcium uniporter complex.
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DOI：
10.1016/j.bbamcr.2015.04.008
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发表时间：
2015-09
期刊：
影响因子：
--
通讯作者：
Rizzuto R
中科院分区：
文献类型：
--
作者：
De Stefani D;Patron M;Rizzuto R
线粒体钙单向转运蛋白（MCU）是线粒体内膜介导电泳Ca ~（2+）摄取到基质中的关键蛋白。它在整体钙信号的形成和有氧代谢以及细胞凋亡的控制中起着重要作用。线粒体钙信号传导的两个特征已经知道了很长时间：i）线粒体Ca 2+摄取在细胞和组织中广泛变化，以及ii）通道开放强烈依赖于线粒体外Ca 2+浓度，在静息[Ca 2 +]时具有低活性，并且一旦钙信号传导被激活就具有高容量。这种复杂性需要一种专门的分子机制，其中几种主要成分可以聚集在一起，以满足能量需求并保护免受有毒刺激。与此相一致，MCU现在被认为是称为MCU复合物的大分子复合物的一部分。我们对MCU复合物的结构和功能的理解正在迅速增长，揭示了一种意想不到的复杂性，突出了线粒体Ca 2+信号的多效性作用。
The Mitochondrial Calcium Uniporter (MCU) is the critical protein of the inner mitochondrial membrane mediating the electrophoretic Ca2+ uptake into the matrix. It plays a fundamental role in the shaping of global calcium signaling and in the control of aerobic metabolism as well as apoptosis. Two features of mitochondrial calcium signaling have been known for a long time: i) mitochondrial Ca2+ uptake widely varies among cells and tissues, and ii) channel opening strongly relies on the extramitochondrial Ca2+ concentration, with low activity at resting [Ca2+] and high capacity as soon as calcium signaling is activated. Such complexity requires a specialized molecular machinery, with several primary components can be variably gathered together in order to match energy demands and protect from toxic stimuli. In line with this, MCU is now recognized to be part of a macromolecular complex known as the MCU complex. Our understanding of the structure and function of the MCU complex is now growing promptly, revealing an unexpected complexity that highlights the pleiotropic role of mitochondrial Ca2+ signals.