IgG subclass antibodies to herpes simplex virus.
IgG subclass antibodies to herpes simplex virus.
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单纯疱疹病毒的 IgG 亚类抗体。
DOI：
10.1093/infdis/151.5.929
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Reimer,CB
中科院分区：
文献类型：
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作者：
Coleman,RM;Nahmias,AJ;Williams,SC;Phillips,DJ;Black,CM;Reimer,CB
为检测人单纯疱疹病毒(HSV)免疫球蛋白G亚类抗体，用酶联免疫吸附试验检测了几种小鼠抗人单纯疱疹病毒(HSV)抗原的单抗。不同单抗的不同结果表明，在研究抗体对感染性病原体的反应时，需要具有良好特性的试剂。检测的204份血清来自157名临床表现不同形式的HSV感染患者和几名对照组。IgGI抗体在几乎所有HSV感染者中都被证实，并且是最初出现在初级生殖器感染中的抗体。在急性期血清中检测到IgG2、IgG3和IgG4抗体，最常见的是复发性生殖器疱疹患者，但没有一例初发感染患者。男性患者的血清中出现IgG4抗体的频率明显高于女性患者。
Several mouse monoclonal antibodies specific for human IgGl, IgG2, IgG3, and IgG4 were evaluated by enzyme-linked immunosorbent assay to detect human IgG subclass antibodies to herpes simplex virus (HSV) antigens. The variable results with different monoclonal antibodies point to the need for well-characterized reagents in the study of antibody responses to infectious agents. The 204 sera tested were obtained from 157 patients with various forms of clinically manifest HSV infections and from several controls. IgGI antibodies were demonstrated in almost all HSV-infected subjects and were the first antibodies to appear in primary genital infections. IgG2, IgG3, and IgG4 antibodies were detected in acute-phase sera, most often in patients with recurrent genital herpes but in none of those with primary infections. IgG4 antibodies occurred significantly more frequently in sera from men than in those from women with recurrent genital infections.