Thought disorder and nucleus accumbens in childhood: a structural MRI study
Thought disorder and nucleus accumbens in childhood: a structural MRI study
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DOI：
10.1016/j.pscychresns.2003.10.001
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发表时间：
2004-01-15
影响因子：
2.3
通讯作者：
Caplan, R
中科院分区：
文献类型：
--
作者：
Ballmaier, M;Toga, AW;Caplan, R
思维障碍被描述为成人和儿童精神分裂症的一个标志性特征。伏隔核(NAC)是调节丘脑皮质回路中信息流的门控和信息处理的关键部位。本研究的目的是调查12名精神分裂症儿童和15名年龄匹配的健康儿童的思维障碍测量与高分辨率体积磁共振成像分析获得的NAC体积之间的关系。尽管精神分裂症儿童和正常儿童的NAC容量在统计学上没有显著差异，但对特定思维障碍特征的倾向与NAC容量显著相关。较小的左侧NAC容量与在线复习词汇选择、句法和参考文献中的语言错误显著相关。另一方面，在计划和组织思维中，对错误的在线修复的使用不足与正确的NAC容量的减少显著相关。这项初步研究的结果表明，NAC与儿童特定的思维模式有关。他们还认为，NAC的皮质下功能可能反映了大脑半球的专门化模式，其中左侧化用于修正语言错误，右侧化用于修复与思维组织有关的策略。(C)2003爱思唯尔爱尔兰有限公司。保留所有权利。
Thought disorder has been described as a hallmark feature in both adult and childhood-onset schizophrenia. The nucleus accumbens (NAc) has been repeatedly proposed as a critical station for modulating gating of information flow and processing of information within the thalamocortical circuitry. The aim of the present study was to investigate the relationship of thought disorder measures, which were administered to 12 children with schizophrenia and 15 healthy age-matched controls, and NAc volumes obtained from high-resolution volumetric magnetic resonance imaging analyses. The propensity for specific thought disorder features was significantly related to NAc volumes, despite no statistically significant differences in the NAc volumes of children with schizophrenia and normal children. Smaller left NAc volumes were significantly related to poor on-line revision of linguistic errors in word choice, syntax and reference. On the other hand, underuse of on-line repair of errors in planning and organizing thinking was significantly associated with decreased right NAc volumes. The results of this pilot study suggest that the NAc is implicated in specific thought patterns of childhood. They also suggest that subcortical function in the NAc might reflect hemispheric specialization patterns with left lateralization for revision of linguistic errors and right lateralization for repair strategies involved in the organization of thinking. (C) 2003 Elsevier Ireland Ltd. All rights reserved.