THE ACCURACY OF A PHARMACOKINETIC THEOPHYLLINE PREDICTOR USING ONCE DAILY DOSING
THE ACCURACY OF A PHARMACOKINETIC THEOPHYLLINE PREDICTOR USING ONCE DAILY DOSING
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DOI：
10.1111/j.1365-2125.1987.tb03173.x
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发表时间：
1987-09-01
影响因子：
3.4
通讯作者：
PEAKE, MD
中科院分区：
文献类型：
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作者：
CHRYSTYN, H;MULLEY, BA;PEAKE, MD
1评价了基于贝叶斯分析的计算机药代动力学预测方法对茶碱口服缓释制剂的准确性。2测定7个中心83例患者在不同环境下的24 h血药浓度-时间曲线。3根据研究前、研究中和研究后不同亚组患者的单一血药浓度进行贝叶斯分析，得到24 h茶碱血药浓度的修正预测值。比较预测值和实测值，每日一次给药，峰值浓度的平均预测误差(BIAS)为0.05mgL-1，谷值浓度的平均预测误差(BISA值)为0.04mgL-1。相应的均方根预测误差(精度)分别为2.59和1.17mgL-1。4这种准确性被认为对临床用途绰绰有余。5该技术可与多种其他药物一起使用，并可构成常规治疗药物监测服务的宝贵部分。
1 The accuracy of a computer based pharmacokinetic prediction method based on Bayesian analysis has been evaluated for an oral slow release form of theophylline. 2 In 83 patients from seven centres 24 h serum theophylline concentration-time profiles were measured under a variety of circumstances. 3 Revised predictions of 24 h serum theophylline concentration profiles were generated by Bayesian analysis using single serum drug concentrations taken before, during and after the study days in different subgroups of those patients. Comparing the predicted and measured profiles the mean prediction error (bias) was 0.05 mg l-1 for peak concentrations and 0.04 mg l-1 for trough concentrations during once daily dosing. The corresponding root mean squared prediction errors (precision) were 2.59 and 1.17 mg l-1, respectively. 4 This accuracy is considered more than adequate for clinical purposes. 5 The technique can be used with a variety of other drugs and can form a valuable part of a routine therapeutic drug monitoring service.