How Dynein Moves Along Microtubules.
How Dynein Moves Along Microtubules.
复制标题
DOI：
10.1016/j.tibs.2015.11.004
复制
发表时间：
2016-01
影响因子：
13.8
通讯作者：
Vale RD
中科院分区：
文献类型：
--
作者：
Bhabha G;Johnson GT;Schroeder CM;Vale RD
细胞质动力蛋白是ATP酶AAA家族的一员，驱动大量细胞内物质向微管负端进行性运动。在这里，我们总结了动力蛋白的结构和运动特性，并突出显示了区别于驱动蛋白-1和肌球蛋白V，两个充分研究的运输马达的特点。从最近的晶体和冷冻EM结构，以及高分辨率的单分子研究的整合信息，我们还讨论了动力蛋白如何偏置它的运动在一个方向沿着微管轨道的模型，并提出了一个电影，说明这些原则。
Cytoplasmic dynein, a member of the AAA family of ATPases, drives the processive movement of numerous intracellular cargos towards the minus end of microtubules. Here, we summarize the structural and motile properties of dynein and highlight features that distinguish this motor from kinesin-1 and myosin V, two well-studied transport motors. Integrating information from recent crystal and cryo-EM structures as well as high-resolution single molecule studies, we also discuss models for how dynein biases its movement in one direction along a microtubule track, and present a movie that illustrates these principles.