The acceleration of implant osseointegration by liposomal Wnt3a
The acceleration of implant osseointegration by liposomal Wnt3a
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DOI：
10.1016/j.biomaterials.2010.08.045
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发表时间：
2010-12-01
期刊：
影响因子：
14
通讯作者：
Helms, Jill A.
中科院分区：
文献类型：
--
作者：
Popelut, Antoine;Rooker, Scott M.;Helms, Jill A.
基于wnt的组织再生策略的优势在于wnt在愈合中发挥的核心作用。组织损伤会在损伤部位触发局部Wnt激活，几乎所有组织（包括骨、神经组织、心肌和表皮）的修复和/或再生都需要这种Wnt信号。我们开发了一种基于生物学的方法，在笔状种植体组织中产生短暂的Wnt信号升高，这样做可以加速种植体周围的骨形成。我们随后的分子和细胞分析为这种促成骨作用的基础提供了机制见解。鉴于Wnt信号在骨形成中的重要作用，这种基于蛋白质的方法可能在种植体骨整合中有广泛的应用。(C) 2010 Elsevier Ltd.版权所有。
The strength of a Wnt-based strategy for tissue regeneration lies in the central role that Wnts play in healing. Tissue injury triggers local Wnt activation at the site of damage, and this Wnt signal is required for the repair and/or regeneration of almost all tissues including bone, neural tissues, myocardium, and epidermis. We developed a biologically based approach to create a transient elevation in Wnt signaling in pen-implant tissues, and in doing so, accelerated bone formation around the implant. Our subsequent molecular and cellular analyses provide mechanistic insights into the basis for this pro-osteogenic effect. Given the essential role of Wnt signaling in bone formation, this protein-based approach may have widespread application in implant osseointegration. (C) 2010 Elsevier Ltd. All rights reserved.