Mucorales-specific T cells emerge in the course of invasive mucormycosis and may be used as a surrogate diagnostic marker in high-risk patients
Mucorales-specific T cells emerge in the course of invasive mucormycosis and may be used as a surrogate diagnostic marker in high-risk patients
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DOI：
10.1182/blood-2011-07-366526
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发表时间：
2011-11-17
期刊：
影响因子：
20.3
通讯作者：
Luppi, Mario
中科院分区：
文献类型：
--
作者：
Potenza, Leonardo;Vallerini, Daniela;Luppi, Mario
研究了28例血液病患者治疗过程中粘膜特异性T细胞的变化。3例确诊为侵袭性毛霉病（IM）， 17例有已知来源但非IM的感染，8例在观察期间从未发烧。粘膜特异性T细胞只能在IM患者中检测到，无论是在诊断时还是在IM的整个过程中，但在感染消退之前或之后很长时间内都不能检测到。这些T细胞主要产生IL-4， ifn - γ, IL-10，以及较小程度的IL-17，属于CD4（+）或CD8（+）亚群。产生ifn - γ的特异性T细胞能够直接诱导粘膜菌丝的损伤。没有IM的25例患者中没有粘膜特异性T细胞。特异性T细胞有助于人体对真菌的免疫反应，并可作为IM的替代诊断标志物。(血。2011;118 (20):5416 - 5419)
Mucorales-specific T cells were investigated in 28 hematologic patients during the course of their treatment. Three developed proven invasive mucormycosis (IM), 17 had infections of known origin but other than IM, and 8 never had fever during the period of observation. Mucorales-specific T cells could be detected only in patients with IM, both at diagnosis and throughout the entire course of the IM, but neither before nor for long after resolution of the infection. Such T cells predominantly produced IL-4, IFN-gamma, IL-10, and to a lesser extent IL-17 and belonged to either CD4(+) or CD8(+) subsets. The specific T cells that produced IFN-gamma were able to directly induce damage to Mucorales hyphae. None of the 25 patients without IM had Mucorales-specific T cells. Specific T cells contribute to human immune responses against fungi of the order Mucorales and could be evaluated as a surrogate diagnostic marker of IM. (Blood. 2011;118(20):5416-5419)