Structure and neurotrophic activity of novel sesqui-neolignans from the pericarps of Illicium fargesii
Structure and neurotrophic activity of novel sesqui-neolignans from the pericarps of Illicium fargesii
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DOI：
10.1016/j.tet.2007.03.063
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发表时间：
2007-05-14
期刊：
影响因子：
2.1
通讯作者：
Fukuyama, Yoshiyasu
中科院分区：
文献类型：
--
作者：
Moriyama, Miyako;Huang, Jian-Mei;Fukuyama, Yoshiyasu
从八角（Illicium fargesii）果皮的甲醇提取物中分离得到三个新的倍半新木脂素（1）和两个新的倍半新木脂素A和B（2和3），以及两个已知的倍半新木脂素大甘草素（4）和异杜松子醇（5）。化合物1-3是含有多种非芳香环的倍半新木脂素的第二个三个例子，并且提出了它们从chavicol的合理生物合成路线。在分离的倍半-新木脂素中，已发现在原代培养的大鼠皮层神经元中，异杜松醇在0.1至10 μ M的浓度范围内表现出神经突生长促进活性。(C)2007爱思唯尔有限公司保留所有权利。
The structures of three new sesqui-neolignans, fargenin (1) and fargenones A and B (2 and 3), together with two previously known sesqui-neolignans, macranthol (4) and isodunnianol (5), isolated from the methanol extract of the pericarps of Illicium fargesii were elucidated on the basis of spectroscopic data. Compounds 1-3 are the second three examples of the sesqui-neolignans that contain a variety of nonaromatic rings, and their plausible biosynthetic routes from chavicol are proposed. Among the isolated sesqui-neolignans, isodunnianol has been found to exhibit neurite outgrowth-promoting activity at the concentration ranging from 0.1 to 10 mu m in the primary cultured rat cortical neurons. (C) 2007 Elsevier Ltd. All rights reserved.