Superoxide anions in the paraventricular nucleus mediate cardiac sympathetic afferent reflex in insulin resistance rats
Superoxide anions in the paraventricular nucleus mediate cardiac sympathetic afferent reflex in insulin resistance rats
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DOI：
10.1111/apha.12405
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发表时间：
2014-12
影响因子：
6.3
通讯作者：
Hai-Jian Sun;Hong Zhou;X.‐M. Feng;Qing Gao;L. Ding;C-S Tang;Guo-Qing Zhu;Ye-Bo Zhou
中科院分区：
文献类型：
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作者：
Hai-Jian Sun;Hong Zhou;X.‐M. Feng;Qing Gao;L. Ding;C-S Tang;Guo-Qing Zhu;Ye-Bo Zhou
心脏交感传入反射（CSAR）参与交感神经过度兴奋。超氧阴离子和血管紧张素II（Ang II）机制与室旁核（PVN）中的交感神经流出和CSAR相关。本研究旨在研究PVN超氧阴离子是否介导果糖诱导的胰岛素抵抗（IR）大鼠的CSAR和Ang II诱导的CSAR增强反应。
Cardiac sympathetic afferent reflex (CSAR) participates in sympathetic over‐excitation. Superoxide anions and angiotensin II (Ang II) mechanisms are associated with sympathetic outflow and CSAR in the paraventricular nucleus (PVN). This study was designed to investigate whether PVN superoxide anions mediate CSAR and Ang II‐induced CSAR enhancement response in fructose‐induced insulin resistance (IR) rats.