Development of the Nimbus/University of Pittsburgh innovative ventricular assist system.
Development of the Nimbus/University of Pittsburgh innovative ventricular assist system.
复制标题
Nimbus/匹兹堡大学创新心室辅助系统的开发。
DOI：
10.1016/s0003-4975(99)00582-2
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Borovetz,HS
中科院分区：
文献类型：
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作者：
Butler,KC;Dow,JJ;Litwak,P;Kormos,RL;Borovetz,HS
自1992年以来，Nimbus公司和匹兹堡大学的McGowan人工器官开发中心一直是旋转血泵技术倡议的合作者。目前，一个主要的焦点是一个创新的心室辅助系统（IVAS），具有植入式，电动轴流式血泵。除了血泵，一个主要的发展项目是电子控制器和控制算法，用于调制泵的速度，以响应不断变化的物理demands.MethodsMethods方法在发展IVAS包括计算流体动力学模型的泵的内部流场，流动可视化的流场使用基于激光的成像，计算机模拟血泵的生理相互作用，振动声学监测，以及广泛的体内测试计划。结果迄今为止的结果（如下所示）包括带浸血轴承的血泵的成功体内测试，以及该应用中振动声学监测的可行性论证。结论这种独特的工业经验和技术与大学研究和开发中心的融合极大地促进了IVAS项目的进展。
BackgroundNimbus Inc, and the University of Pittsburgh’s McGowan Center for Artificial Organ Development have been collaborators on rotary blood pump technology initiatives since 1992. Currently, a major focus is an innovative ventricular assist system (IVAS) that features an implantable, electrically powered axial flow blood pump. In addition to the blood pump, a major development item is the electronic controller and the control algorithm for modulating pump speed in response to varying physical demand.MethodsMethods used in developing the IVAS include computational fluid dynamic modeling of the pump’s interior flow field, flow visualization of the flow field using laser-based imaging, computer simulation of blood pump-physiological interactions, vibroaccoustic monitoring, and an extensive in vivo test program.ResultsResults to date, which are presented below, include successful in vivo tests of blood pumps with blood-immersed bearings, and feasibility demonstration of vibroacoustic monitoring in this application.ConclusionsThis unique blend of industrial experience and technologies with the University-based Research and Development Center has greatly enhanced the progress made on this IVAS project.