Differentiation of transitional zone prostate cancer from benign hyperplasia nodules: Evaluation of discriminant criteria at multiparametric MRI
Differentiation of transitional zone prostate cancer from benign hyperplasia nodules: Evaluation of discriminant criteria at multiparametric MRI
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DOI：
10.1016/j.crad.2013.01.018
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发表时间：
2013-06-01
影响因子：
2.6
通讯作者：
Rouviere, O.
中科院分区：
文献类型：
--
作者：
Chesnais, A. L.;Niaf, E.;Rouviere, O.
目的：为了评估地形和磁共振成像（MRI）的特点，在表征前列腺移行区（TZ）nodes.MATERIALS和METHODS：两名放射科医生评价所有TZ结节可见在多参数MRI在52例连续患者进行根治性前列腺切除术。放射科医生评估了地形（前后和上下位置，矢状中线交叉）和T2加权（形状，囊的存在和清晰度，轮廓的清晰度，囊肿的存在）特征，表观扩散系数（ADC），以及来自动态对比增强（DCE）成像的8个半定量和定量增强参数。结节的性质进行了评估，使用椎间盘切除标本。结果：137个结节（良性117个，恶性20个）进行了评价。根据5种统计学方法中的至少4种，平均ADC值、所有地形图和所有T2加权特征是恶性肿瘤的显著预测因子。特别是，20/20和18/20的癌症分别涉及TZ的前三分之一和顶端三分之一。肿瘤与良性结节的增强参数无显著差异。通过评估存在的囊肿，结节的包膜，其前后和上下位置，111/117良性结节被正确诊断，没有错误分类任何cancer.CONCLUSION：拓扑结构，T2加权和扩散加权功能可以用来表征TZ结节。DCE成像似乎没有提供额外的信息。(C)2013年皇家放射科医师学院。由爱思唯尔有限公司出版。保留所有权利。
AIM: To assess topographical and magnetic resonance imaging (MRI) features in characterizing prostate transitional zone (TZ) nodules.MATERIALS AND METHODS: Two radiologists evaluated all TZ nodules visible at multiparametric MRI in 52 consecutive patients who underwent radical prostatectomy. The radiologists assessed topographical (anteroposterior and superior-inferior location, crossing of the sagittal midline) and T2-weighted ( shape, presence and distinctness of capsule, distinctness of contours, presence of cysts) features, the apparent diffusion coefficient (ADC), and eight semi-quantitative and quantitative enhancement parameters derived from dynamic contrast-enhanced (DCE) imaging. The nature of the nodules was assessed using prostatectomy specimens. Five statistical methods taking into account multiple testing were used.RESULTS: One hundred and thirty-seven nodules (117 benign, 20 malignant) were evaluated. Mean ADC, all topographical, and all T2-weighted features were significant predictors of malignancy according to at least four out of the five statistical methods. Particularly, 20/20 and 18/20 cancers involved the anterior and apical third of the TZ, respectively. None of the enhancement parameters was significantly different between cancers and benign nodules. By assessing the presence of cysts, the nodules' capsule, and their anteroposterior and superior-inferior location, 111/117 benign nodules were correctly diagnosed, without misclassifying any cancer.CONCLUSION: Topographical, T2-weighted, and diffusion-weighted features can be used to characterize TZ nodules. DCE imaging does not seem to provide additional information. (C) 2013 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.