Treatment of invasive retinoblastoma in a murine model using an oncolytic picornavirus
Treatment of invasive retinoblastoma in a murine model using an oncolytic picornavirus
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DOI：
10.1158/0008-5472.can-07-2352
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发表时间：
2007-11-15
期刊：
影响因子：
11.2
通讯作者：
Hurwitz, Richard L.
中科院分区：
文献类型：
--
作者：
Wadhwa, Lalita;Hurwitz, Mary Y.;Hurwitz, Richard L.
视网膜母细胞瘤是儿童最常见的眼膜内恶性肿瘤，其转移最初是侵入脉络膜和视神经。转移性视网膜母细胞瘤没有有效的治疗方法，特别是当中枢神经系统（CNS）受累时，预防这种并发症是治疗的重点。塞内卡谷病毒（SVV-001）是一种有条件复制能力的小核糖核酸病毒，对正常人类细胞无致病性，但能在体外杀死人类视网膜母细胞瘤细胞，IC50为
Retinoblastoma, the most common intrancular malignancy of childhood, metastasizes by initial invasion of the choroid and the optic nerve. There is no effective treatment for metastatic retinoblastoma, especially when the central nervous system (CNS) is involved, and prevention of this complication is a treatment priority. Seneca Valley Virus (SVV-001) is a conditionally replication-competent picornavirus that is not pathogenic to normal human cells but can kill human retinoblastoma cells in vitro with an IC50 of