Genes involved in senescence and immortalization
Genes involved in senescence and immortalization
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DOI：
10.1016/s0955-0674(00)00155-1
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发表时间：
2000-12-01
影响因子：
7.5
通讯作者：
Weinberg, RA
中科院分区：
文献类型：
--
作者：
Lundberg, AS;Hahn, WG;Weinberg, RA
衰老现在被理解为细胞响应于几种不同的细胞生理过程（包括增殖、癌基因活化和氧自由基毒性）而采取的最终表型状态。端粒维持在永生化中的作用以及p16（INK4A）、p19（ARF）、p53等基因在衰老中的作用正在进一步阐明。我们对细胞衰老和永生化的理解继续取得重大进展。
Senescence is now understood to be the final phenotypic state adopted by a cell in response to several distinct cell physiological processes, including proliferation, oncogene activation and oxygen free radical toxicity. The role of telomere maintenance in immortalization and the roles of p16(INK4A) p19(ARF), p53 and other genes in senescence are being further elucidated. Significant progress continues to be made in our understanding of cellular senescence and immortalization.