Further evidence of the developmental origins of osteoarthritis: results from the Hertfordshire Cohort Study.
Further evidence of the developmental origins of osteoarthritis: results from the Hertfordshire Cohort Study.
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DOI：
10.1017/s2040174414000373
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发表时间：
2014-12
影响因子：
1.7
通讯作者：
Dennison EM
中科院分区：
文献类型：
--
作者：
Clynes MA;Parsons C;Edwards MH;Jameson KA;Harvey NC;Sayer AA;Cooper C;Dennison EM
研究人员提出出生体重与手部和腰椎骨关节炎(OA)之间存在联系。在这项研究中，我们试图通过调查赫特福德郡队列研究(HCS)参与者的早期生活发育与手部、膝盖和髋部骨关节炎的临床和放射诊断之间的关系来扩展这些观察。有222名男性和222名女性的数据可用。临床骨关节炎的定义依据美国风湿病学会(ACR)标准。拍摄膝关节和髋部的X线片，并根据骨赘的存在和总体Kellgren和Lawrence(KL)评分进行分级。第1年体重越低，临床手部骨关节炎发生率越高(OR 1.396，95%CI1.05，1.85，p=0.021)。出生体重较低的人更有可能患有髋部骨赘(OR 1.512，95%CI1.14，2.00，p=0.004)，在调整混杂因素后，这一点仍然很强。此外，在调整混杂因素后，一年内体重低也与膝关节外侧骨赘数量增加相关(OR 1.388，95%CI1.01，1.91p=0.043)。我们发现了早期生活因素与成人骨性关节炎之间关系的进一步证据。这些发现与之前的研究一致。
Investigators have suggested a link between birth weight and both hand and lumbar spine osteoarthritis (OA). In this study, we sought to extend these observations by investigating relationships between growth in early life, and clinical and radiological diagnoses of OA at the hand, knee and hip, among participants from the Hertfordshire Cohort Study (HCS). Data were available for 222 men and 222 women. Clinical OA was defined based on American College of Rheumatology (ACR) criteria. Radiographs were taken of the knees and hips, and graded for the presence of osteophytes and overall Kellgren and Lawrence (KL) score. Lower weight at year one was associated with higher rates of clinical hand OA (OR 1.396, 95% CI 1.05, 1.85, p=0.021). Individuals with lower birth weights were more likely to have hip osteophytes, (OR 1.512, 95% CI 1.14, 2.00, p=0.004) and this remained robust after adjustment for confounders. Furthermore, a low weight at one year was also associated with a higher osteophyte number in the lateral compartment of the knee, after adjustment for confounders (OR 1.388, 95% CI 1.01, 1.91 p=0.043). We have found further evidence of a relationship between early life factors and adult OA. These findings accord with previous studies.