Asymmetric Synthesis of 3,4-Dihydroquinolin-2-ones via a Stereoselective Palladium-Catalyzed Decarboxylative [4+2]-Cycloaddition
Asymmetric Synthesis of 3,4-Dihydroquinolin-2-ones via a Stereoselective Palladium-Catalyzed Decarboxylative [4+2]-Cycloaddition
复制标题
通过立体选择性钯催化脱羧[4 2]-环加成不对称合成 3,4-二氢喹啉-2-酮
DOI：
10.1021/acs.orglett.7b03467
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发表时间：
2018-01-05
期刊：
影响因子：
5.2
通讯作者：
Deng, Wei-Ping
中科院分区：
文献类型：
--
作者：
Jin, Jing-Hai;Wang, Hao;Deng, Wei-Ping
采用P-手性单磷配体BI-DIME，研究了4-乙烯基苯并恶嗪酮与羧酸的[4 + 2]-脱羧环加成反应，得到了一系列结构不同的带有两个相邻立体中心的3，4-二氢喹啉-2-酮，产率中等至良好，立体选择性良好至优异。
An efficient, palladium-catalyzed, decarboxylative [4 + 2]-cycloaddition of 4-vinyl benzoxazinanones with carboxylic acids has been developed with the employment of P-chiral mono phosphorus ligand BI-DIME, affording a series of structurally diverse 3,4-dihydroquinolin-2-ones bearing two contiguous stereogenic centers in moderate to good yields with good to excellent stereoselectivities.