Anterior cingulate cortex activation during cognitive interference in schizophrenia
Anterior cingulate cortex activation during cognitive interference in schizophrenia
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DOI：
10.1176/appi.ajp.161.4.707
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发表时间：
2004-04-01
影响因子：
17.7
通讯作者：
Bush, G
中科院分区：
文献类型：
--
作者：
Heckers, S;Weiss, AP;Bush, G
背景资料：以前的研究报告的证据表明，在前扣带皮层的患者schizophrenia.Method的结构和功能异常：作者研究了19例男性慢性精神分裂症患者和15名健康男性比较科目与功能磁共振成像和新的多源干扰任务，任务旨在引起强大的背侧前扣带皮层激活在个别科目。组平均和个人（区域的利益为基础）大脑激活模式进行了比较，在控制和干扰trials.Results的性能（反应时间和准确性）之间没有差异健康受试者和精神分裂症患者。干扰和中性阻滞的比较显示，93%（N = 14）的健康受试者和84%（N = 16）的精神分裂症受试者的前额叶皮层内侧壁激活。67%（N = 10）的健康受试者，但只有16%（N = 3）的精神分裂症受试者显示最大内侧壁激活背侧前扣带皮层。结论：多源干扰任务产生强大的激活在内侧壁的前额叶皮层在认知干扰。个体激活模式的分析揭示了精神分裂症患者的内侧壁异常。
Background: Previous studies have reported evidence of structural and functional abnormalities in the anterior cingulate cortex of patients with schizophrenia.Method: The authors studied 19 male patients with chronic schizophrenia and 15 healthy male comparison subjects with functional magnetic resonance imaging and the novel Multi-Source Interference Task, a task designed to elicit robust dorsal anterior cingulate cortex activation in individual subjects. Group averaged and individual (region-of-interest-based) brain activation patterns were compared during the performance of control and interference trials.Results: Performance (reaction times and accuracy) did not differ between healthy subjects and patients with schizophrenia. Comparison of interference and neutral blocks revealed activation in the medial wall of the prefrontal cortex in 93% (N = 14) of the healthy subjects and 84% (N = 16) of the subjects with schizophrenia. Sixty-seven percent (N = 10) of the healthy subjects but only 16% (N = 3) of the subjects with schizophrenia displayed maximum medial wall activation within the dorsal anterior cingulate cortex.jConclusions: The Multi-Source Interference Task produced robust activation in the medial wall of the prefrontal cortex during cognitive interference. Analysis of individual activation patterns revealed medial wall abnormalities in schizophrenia patients.