Lempel-Ziv complexity in schizophrenia: A MEG study
Lempel-Ziv complexity in schizophrenia: A MEG study
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DOI：
10.1016/j.clinph.2011.04.011
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发表时间：
2011-11-01
影响因子：
4.7
通讯作者：
Jose Lopez-Ibor, Juan
中科院分区：
文献类型：
--
作者：
Fernandez, Alberto;Lopez-Ibor, Maria-Ines;Jose Lopez-Ibor, Juan
目的：神经发育-神经退行性争论是精神分裂症（SCH）神经病理学基础领域的一个基本问题。神经生理学技术几乎没有参与此类争论，但非线性分析方法可能会对此有所贡献。方法：15 名符合 DSM IV-TR SCH 标准的患者（年龄范围 23-42 岁）和 15 名性别和年龄匹配的对照受试者（年龄范围 23-42 岁）接受了静息态脑磁图评估和 Lempel-Ziv 复杂性 (LZC) 计算分数。结果：回归分析表明 LZC 值强烈依赖于年龄。对照组的复杂性得分随着年龄的增加而增加，而 SCH 患者的 LZC 值则逐渐降低。包括 LZC 评分、年龄和两个变量的相互作用的逻辑模型允许对患者和对照进行高灵敏度和特异性的分类。结论：结果表明 SCH 患者未能遵循复杂性随年龄增加的“正常”过程。此外，SCH 患者表现出随年龄变化的复杂性评分显着降低，从而与神经退行性疾病中观察到的模式相似。意义：我们的结果 支持 SCH 进行性缺陷的概念，这与基本神经发育改变的存在并不矛盾。 (C) 2011 年国际临床神经生理学联合会。由爱思唯尔爱尔兰有限公司出版。保留所有权利。
Objective: The neurodevelopmental-neurodegenerative debate is a basic issue in the field of the neuropathological basis of schizophrenia (SCH). Neurophysiological techniques have been scarcely involved in such debate, but nonlinear analysis methods may contribute to it.Methods: Fifteen patients (age range 23-42 years) matching DSM IV-TR criteria for SCH, and 15 sex-and age-matched control subjects (age range 23-42 years) underwent a resting-state magnetoencephalographic evaluation and Lempel-Ziv complexity (LZC) scores were calculated.Results: Regression analyses indicated that LZC values were strongly dependent on age. Complexity scores increased as a function of age in controls, while SCH patients exhibited a progressive reduction of LZC values. A logistic model including LZC scores, age and the interaction of both variables allowed the classification of patients and controls with high sensitivity and specificity.Conclusions: Results demonstrated that SCH patients failed to follow the "normal'' process of complexity increase as a function of age. In addition, SCH patients exhibited a significant reduction of complexity scores as a function of age, thus paralleling the pattern observed in neurodegenerative diseases.Significance: Our results support the notion of a progressive defect in SCH, which does not contradict the existence of a basic neurodevelopmental alteration. (C) 2011 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.