Biodegradable MRI Visible Drug Eluting Stent Reinforced by Metal Organic Frameworks.
Biodegradable MRI Visible Drug Eluting Stent Reinforced by Metal Organic Frameworks.
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DOI：
10.1002/adhm.202000136
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发表时间：
2020-07
影响因子：
10
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中科院分区：
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金属有机框架（MOFs）在许多领域中具有应用。然而，基于M0F的"治疗诊断"宏观尺度装置的开发尚未实现。在这里，我们开发了肝素涂层的生物相容性MOF/聚（ε-己内酯）（PCL）“治疗诊断”支架，其中NH2-MIL-101（Fe）封装并释放雷帕霉素（一种免疫抑制药物）。与不可见的聚合物支架相比，这些支架在离体磁共振成像（MRI）中也可作为显著的对比源。肝素和雷帕霉素的体外释放模式分别可以确保一种程序化模型，以防止动脉支架置入后立即发生血液凝固，并在较长时间内防止狭窄。由于MOFs中存在可水解官能团，支架在各种条件下的降解试验中显示出高度生物降解性。此外，在MOF复合的情况下不存在机械强度或柔性的折衷。我们在这里描述的系统承诺在宏观治疗诊断设备的许多生物医学应用。M0F@PCL的使用可以使医疗装置MRI可见，同时充当治疗剂的载体。
Metal-Organic Frameworks (MOFs) have applications in numerous fields. However, the development of MOF-based ‘theranostic’ macro-scale devices has not been achieved. Here, we develop heparin-coated biocompatible MOF/ Poly(ε-caprolactone) (PCL) ‘theranostic’ stents, where NH2-MIL-101(Fe) encapsulates and releases rapamycin (an immunosuppressive drug). These stents also act as a remarkable source of contrast in ex vivo magnetic resonance imaging (MRI) compared to the invisible polymeric stent. The in vitro release patterns of heparin and rapamycin respectively can ensure a type of programmed model to prevent blood coagulation immediately after stent placement in the artery, and stenosis over a longer term. Due to the presence of hydrolysable functionalities in MOFs, the stents are shown to be highly biodegradable in degradation tests under various conditions. Furthermore, there is no compromise of mechanical strength or flexibility with MOF compositing. The system we describe here promises many biomedical applications in macroscale theranostic devices. The use of MOF@PCL can render a medical device MRI-visible while simultaneously acting as a carrier for therapeutic agents.