Dendritic Release of Neurotransmitters.
Dendritic Release of Neurotransmitters.
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神经递质的树突释放。
DOI：
10.1002/cphy.c160007
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发表时间：
2016-12-06
影响因子：
5.8
通讯作者：
Rice ME
中科院分区：
文献类型：
--
作者：
Ludwig M;Apps D;Menzies J;Patel JC;Rice ME
神经活性物质通过胞吐作用从树突的释放令人惊讶地广泛，并且不限于特定类别的递质：它发生在多个脑区域中，并且包括一系列神经肽、经典神经递质和信号分子，如一氧化氮、一氧化碳、ATP和花生四烯酸。本文就分泌加压素和催产素的下丘脑神经内分泌细胞和分泌多巴胺的中脑神经元作一综述。对于这两个模型系统，树突状细胞释放的刺激，机制和生理功能已经被探索得比其他神经元和神经活性物质更详细。
Release of neuroactive substances by exocytosis from dendrites is surprisingly widespread and is not confined to a particular class of transmitters: it occurs in multiple brain regions, and includes a range of neuropeptides, classical neurotransmitters and signaling molecules such as nitric oxide, carbon monoxide, ATP and arachidonic acid. This review is focused on hypothalamic neuroendocrine cells that release vasopressin and oxytocin and midbrain neurons that release dopamine. For these two model systems, the stimuli, mechanisms and physiological functions of dendritic release have been explored in greater detail than is yet available for other neurons and neuroactive substances.