Poliomyelitis-like paralysis during recovery from acute bronchial asthma: possible etiology and risk factors.
Poliomyelitis-like paralysis during recovery from acute bronchial asthma: possible etiology and risk factors.
复制标题
急性支气管哮喘恢复期间的脊髓灰质炎样瘫痪：可能的病因和危险因素。
DOI：
10.1542/peds.88.2.276
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发表时间：
1991
期刊：
影响因子：
8
通讯作者：
E. Murphy
中科院分区：
文献类型：
--
作者：
E. Shahar;P. Hwang;C. Niesen;E. Murphy
一个脊髓灰质炎样麻痹性疾病在恢复期间从一个攻击的支气管哮喘描述在两个年幼的孩子。他们分别在13个月和22个月时出现一个或两个下肢的急性弛缓性麻痹和保留的感觉。脑脊液检查显示两个婴儿的蛋白质轻度升高，第二个婴儿的白细胞增多。在第二名患者的鼻拭子和粪便中分离出肠道病毒。电生理学检查发现，弛缓性麻痹急性发作伴运动动作电位缺失和感觉反应正常，高度提示这些婴儿患有运动前角细胞疾病。在病毒性疾病引发的急性支气管哮喘发作期间，免疫抑制、应激和神经毒性药物的多因素设置可能使患者易受脊髓灰质炎病毒以外的肠道病毒对前角细胞的病毒入侵。回顾了22例严重并发症患者的总体经验。
A poliomyelitis-like paralytic disease during recovery from an attack of bronchial asthma is described in two young children. They presented at the age of 13 and 22 months, respectively, with acute flaccid paralysis of one or both lower limbs and preserved sensation. Cerebrospinal fluid examinations revealed mild protein elevation in both and pleocytosis in the second infant. Enteroviruses were isolated in a nasal swab and stools of the second patient. Acute onset of flaccid paralysis with absent motor action potential and normal sensory responses, detected by electrophysiologic studies, are highly suggestive of motor anterior horn cell disease in these infants. A multifactorial setup of immune suppression, stress, and neurotoxic drugs during an acute bronchial asthma attack triggered by a viral disease may render the patient vulnerable to viral invasion of the anterior horn cell with enteroviruses other than poliovirus. The overall experience of 22 patients with this serious complication is reviewed.