Urinary sodium-to-potassium ratio and intake of sodium and potassium among men and women from multiethnic general populations: the INTERSALT Study
Urinary sodium-to-potassium ratio and intake of sodium and potassium among men and women from multiethnic general populations: the INTERSALT Study
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DOI：
10.1038/s41440-019-0263-1
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发表时间：
2019-10-01
影响因子：
5.4
通讯作者：
Stamler, Jeremiah
中科院分区：
文献类型：
--
作者：
Iwahori, Toshiyuki;Miura, Katsuyuki;Stamler, Jeremiah
Na/K比值可能比钠或钾与血压和心血管疾病的相关性更强。随意尿钠/钾比值可以提供及时的现场反馈，并与重复测量，可以提供有用的个人估计的24小时比率。世界卫生组织已经发布了钠和钾摄入量的指导方针，但没有普遍接受的钠/钾比率指导方针。我们使用了来自32个国家（52个人群）的10，065名年龄在20-59岁的个体的INTERSALT研究中获得的24小时和偶然尿电解质排泄的标准化数据。通过相关分析和分层分析评估了偶然尿钠/钾比值与24小时钠和钾排泄量之间的关系。平均24小时钠和钾排泄分别为156.0 mmol/24 h和55.2 mmo 1/24 h;平均24小时尿Na/K摩尔比为3.24。尿钠钾比值与24小时钠、钾排泄量的Pearson相关系数分别为0.42和-0.34，24小时尿钠钾比值的相关系数分别为0.57和-0.48。尿钠/钾比值预测24小时尿钠排泄量为
The Na/K ratio may be more strongly related to blood pressure and cardiovascular disease than sodium or potassium. The casual urine Na/K ratio can provide prompt on-site feedback, and with repeated measurements, may provide useful individual estimates of the 24-h ratio. The World Health Organization has published guidelines for sodium and potassium intake, but no generally accepted guideline prevails for the Na/K ratio. We used standardized data on 24 h and casual urinary electrolyte excretion obtained from the INTERSALT Study for 10,065 individuals aged 20-59 years from 32 countries (52 populations). Associations between the casual urinary Na/K ratio and the 24-h sodium and potassium excretion of individuals were assessed by correlation and stratification analyses. The mean 24-h sodium and potassium excretions were 156.0 mmol/24 h and 55.2 mmo1/24 h, respectively; the mean 24-h urinary Na/K molar ratio was 3.24. Pearson's correlation coefficients (r) for the casual urinary Na/K ratio with 24-h sodium and potassium excretions were 0.42 and -0.34, respectively, and these were 0.57 and -0.48 for the 24-h ratio. The urinary Na/K ratio predicted a 24-h urine Na excretion of