MAJOR GLYCOPROTEIN ANTIGENS THAT INDUCE ANTIBODIES IN AIDS PATIENTS ARE ENCODED BY HTLV-III
MAJOR GLYCOPROTEIN ANTIGENS THAT INDUCE ANTIBODIES IN AIDS PATIENTS ARE ENCODED BY HTLV-III
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DOI：
10.1126/science.2986290
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发表时间：
1985-01-01
期刊：
影响因子：
56.9
通讯作者：
ESSEX, M
中科院分区：
文献类型：
--
作者：
ALLAN, JS;COLIGAN, JE;ESSEX, M
来自获得性免疫缺陷综合征（AIDS）或AIDS相关复合体患者血清以及来自血清阳性健康同性恋者血清的抗体识别感染人T细胞嗜淋巴细胞病毒III型（HTLV III）的细胞中的2种主要糖蛋白。这些糖蛋白gp 160和gp 120由位于HTLV-III基因组3“末端的2.5-腺苷酸酶开放阅读框编码，如通过这些蛋白的放射性标记形式的氨基末端序列分析所确定的。假设gp 160和gp 120代表HTLV-III病毒编码包膜基因产物的主要种类。
Antibodies from the serum of patients with the acquired immune deficiency syndrome (AIDS) or with the AIDS-related complex and from the serum of seropositive healthy homosexuals, recognize 2 major glycoproteins in cells infected with human T-cell lymphotropic virus type III (HTLV III). These glycoproteins, gp160 and gp120, are encoded by the 2.5-kilobase open reading frame located in the 3'' end of the HTLV-III genome, as determined by amino terminus sequence analysis of the radiolabeled forms of these proteins. It is hypothesized that gp160 and gp120 represent the major species of virus-encoded envelope gene products for HTLV-III.