Design and implementation of a multifrequency near-infrared diffuse optical tomography system
Design and implementation of a multifrequency near-infrared diffuse optical tomography system
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DOI：
10.1117/1.2161199
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发表时间：
2006-01-01
影响因子：
3.5
通讯作者：
Nalcioglu, O
中科院分区：
文献类型：
--
作者：
Gulsen, G;Xiong, B;Nalcioglu, O
介绍了一种多频多谱漫射光学层析成像系统的设计与实现。使用了四个波长：665、785、808和830 nm。该系统基于网络分析仪，为激光二极管提供射频调制信号，并测量被检测信号的幅度和相位。使用了从110到280 MHz的六种不同的调制频率。详细介绍了该系统的仪器、标定、数据采集和性能。采用有限元算法求解扩散方程，并在此基础上实现逆求解器，从采集的数据中计算吸收和散射图。对于单个调制频率，一个波长的数据采集在不到2.5分钟的时间内完成。测量的重复性为0.5%的交流强度和0.2度的相位。通过仿真研究对系统的性能进行了评估。采用多频重构算法，利用在不同调制频率下获得的整个数据集得到单一的吸收和散射图像对。结果表明，与单频重建方法相比，多频重建方法提供了更好的图像质量。(c) 2006年光学仪器工程师学会。
The design and implementation of a multifrequency and multispectral diffuse optical tomography system is described. Four wavelengths are utilized: 665, 785, 808, and 830 nm. The system is based on a network analyzer, which provides rf modulation signals for the laser diodes, as well as measures the amplitude and the phase of the detected signals. Six different modulation frequencies ranging from 110 to 280 MHz are used. The details of instrumentation, calibration, data acquisition, and performance of the system are given. A finite element algorithm is used to solve the diffusion equation, and an inverse solver based on this forward solver is implemented to calculate the absorption and scattering maps from the acquired data. Data acquisition for one wavelength is completed in less than 2.5 min for a single modulation frequency. The measurement repeatability is 0.5% in ac intensity and 0.2 deg in phase. The performance of the system is evaluated with phantom studies. A multifrequency reconstruction algorithm is used, in which a single absorption and scattering image pair is obtained using the whole dataset obtained at different modulation frequencies. It is shown that the multifrequency reconstruction approach provides superior image quality compared to the single frequency counterpart. (c) 2006 Society of Photo- Optical Instrumentation Engineers.