Lifetime excess absolute risk for lung cancer due to exposure to radon: results of the pooled uranium miners cohort study PUMA.
Lifetime excess absolute risk for lung cancer due to exposure to radon: results of the pooled uranium miners cohort study PUMA.
复制标题
由于接触氡而导致终生罹患肺癌的绝对风险过高：铀矿工队列研究 PUMA 的结果。
DOI：
10.1007/s00411-023-01049-w
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发表时间：
2024
影响因子：
1.7
通讯作者：
Fenske,N
中科院分区：
文献类型：
--
作者：
Kreuzer,M;Sommer,M;Deffner,V;Bertke,S;Demers,PA;Kelly-Reif,K;Laurier,D;Rage,E;Richardson,DB;Samet,JM;Schubauer-Berigan,MK;Tomasek,L;Wiggins,C;Zablotska,LB;Fenske,N
联合铀矿工分析(PUMA)研究是最大的铀矿工队列，有119,709名矿工，430万人年面临风险，7754人死于肺癌。据报道，根据PUMA研究，在工作水平月(WLM)内对单位累积氡子体暴露的肺癌死亡率的超额相对比率(ERR)估计。根据达到的年龄、暴露开始的时间或暴露时的年龄以及曝光率对ERR/WLM进行修正。这一模式适用于PUMA全队列和1960年 + 次队列，即1960年或以后受雇的长期低氡暴露率和暴露率的矿工。本论文的目的是使用PUMA风险模型以及先前发表的小型铀矿者研究中得出的风险模型来计算每WLM肺癌死亡率的终生超额绝对风险(LEAR)，其中一些研究包含在PUMA中。同样的方法被应用于所有风险模型，即95岁以下的相对风险预测，从18岁到岁每年2 WLM的暴露情景，以及代表欧洲、美国和亚洲混合人口的基线死亡率。根据模型的选择，在PUMA全队列中，每个WLM的估计LEAR分别为5.38 × 10−4或5.57 × 10−4，在PUMA 1960 次队列中，估计的LEAR分别为7.50 × 10−4或7.66 × 10−4。根据以前发表的铀矿者研究报告的风险模型得出的LEAR Per WLM估计值从2.5 × 10−4到9.2 × 10−4。彪马加强了对与氡相关的肺癌LEAR的了解，这是一种将模型转化为政策目的的有用方式。
The Pooled Uranium Miners Analysis (PUMA) study is the largest uranium miners cohort with 119,709 miners, 4.3 million person-years at risk and 7754 lung cancer deaths. Excess relative rate (ERR) estimates for lung cancer mortality per unit of cumulative exposure to radon progeny in working level months (WLM) based on the PUMA study have been reported. The ERR/WLM was modified by attained age, time since exposure or age at exposure, and exposure rate. This pattern was found for the full PUMA cohort and the 1960 + sub-cohort, i.e., miners hired in 1960 or later with chronic low radon exposures and exposure rates. The aim of the present paper is to calculate the lifetime excess absolute risk (LEAR) of lung cancer mortality per WLM using the PUMA risk models, as well as risk models derived in previously published smaller uranium miner studies, some of which are included in PUMA. The same methods were applied for all risk models, i.e., relative risk projection up to <95 years of age, an exposure scenario of 2 WLM per year from age 18–64 years, and baseline mortality rates representing a mixed Euro-American-Asian population. Depending upon the choice of model, the estimated LEAR per WLM are 5.38 × 10−4or 5.57 × 10−4in the full PUMA cohort and 7.50 × 10−4or 7.66 × 10−4in the PUMA 1960 + sub-cohort, respectively. The LEAR per WLM estimates derived from risk models reported for previously published uranium miners studies range from 2.5 × 10−4to 9.2 × 10−4. PUMA strengthens knowledge on the radon-related lung cancer LEAR, a useful way to translate models for policy purposes.