Transfer of malignant traits as opposed to migration of cells: A novel concept to explain metastatic disease
Transfer of malignant traits as opposed to migration of cells: A novel concept to explain metastatic disease
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DOI：
10.1016/j.mehy.2017.01.019
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发表时间：
2017-03-01
影响因子：
4.7
通讯作者：
Abdouh, Mohamed
中科院分区：
文献类型：
--
作者：
Arena, Goffredo Orazio;Arena, Vincenzo;Abdouh, Mohamed
转移性疾病被认为是在细胞扩散到靶器官后发生的。这种理论无法有效地解释某些现象，如转移扩散的模式，晚期转移形成，原发癌和转移之间的不同基因模式，提出了替代模型的需要。最近的发现加强了理论的有效性，支持体液转移的恶性性状，而不是恶性细胞的迁移，以解释癌症患者的转移性疾病。根据这一新的证据，我们想强调一个模型，提供了一个新的视角来解释癌症转移。在我们理论化的系统中，癌细胞释放的遗传物质将通过血液自由或包装在外泌体中旅行。位于来自同一胚胎层的器官中的靶细胞可能由于特异性受体的表达而摄取这种遗传物质。与免疫系统的相互作用将决定这些致癌因子的命运，并将调节它们在血液中循环、整合到基因组中并被转录的能力。我们还假设，细胞膜受体的表达，如整合素，癌症外泌体连接可能是由遗传或获得性抑癌基因突变介导的。(C)2017作者爱思唯尔有限公司出版
Metastatic disease is believed to develop following dissemination of cells to target organs. Inability of this theory to effectively explain certain phenomena such as patterns of metastatic spread, late metastasis formation, different gene patterns between primary cancer and metastasis have brought forward the need for alternative models. Recent discoveries have strengthened the validity of theories supporting a humoral transfer of malignant traits as opposed to migration of malignant cells to explain metastatic disease in cancer patients.In light of this new evidence, we would like to highlight a model that offers a new perspective to explain cancer metastasis. In the system that we theorize, genetic material released by cancer cells would travel, either free or packed in exosomes, through the blood. Target cells located in organs deriving from the same embryological layer might uptake this genetic material due to expression of specific receptors. Interplay with the immune system would determine the fate of these oncofactors and would regulate their ability to circulate in the blood, integrate in the genome and be transcribed. We also hypothesize that the expression of cell membrane receptors such as integrins, to which cancer exosomes ligate might be mediated by inherited or acquired oncosuppressor mutations. (C) 2017 The Authors. Published by Elsevier Ltd.