Parapertussis and pertussis: differences and similarities in incidence, clinical course, and antibody responses.
Parapertussis and pertussis: differences and similarities in incidence, clinical course, and antibody responses.
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DOI：
10.1016/s1201-9712(99)90035-8
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发表时间：
1999-01-01
期刊：
影响因子：
--
通讯作者：
Zackrisson, G
中科院分区：
文献类型：
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作者：
Bergfors, E;Trollfors, B;Zackrisson, G
目的：比较百日咳和百日咳患者中百日咳杆菌抗原的发病率、临床病程和血清学反应。设计：20世纪90年代在瑞典进行了两项研究，当时百日咳疫苗仅用于临床试验。研究一是对临床常规获得的波尔德氏菌培养阳性的患者进行的回顾性研究，研究二是在一项百日咳类毒素疫苗的安慰剂对照试验中积极寻找波尔德氏菌感染的患者。结果：研究一包括58名百日咳患者，研究二包括23名百日咳患者。研究一中，0~6岁儿童百日咳发病率为每百人年0.016例，年龄较大的儿童和成人为0。在研究II中，3个月至3岁儿童的百日咳和百日咳发病率分别为0.2/100人年和16.2/100人年。中位咳嗽天数：百日咳21天，百日咳59天。百日咳患儿百日咳呕吐的比例低于百日咳患儿。百日咳患儿血清细丝凝集素抗体几何均值从6上升到63，百日咳杆菌抗体从4上升到12单位/毫升，与百日咳患儿相似。结论：百日咳杆菌引起的疾病较百日咳杆菌引起的疾病少，且病情轻，病程短。百日咳能诱导出与百日咳相似的抗丝状血凝素和抗百日咳毒素的血清抗体，但不能诱导出抗百日咳毒素的抗体。
OBJECTIVES: To compare the incidence, clinical course, and serologic response to Bordetella antigens in patients with parapertussis and pertussis.DESIGN: Two studies were performed in Sweden during the 1990s, when pertussis vaccines were used only in clinical trials. Study I was a retrospective study of patients with positive Bordetella cultures obtained in clinical routine, and study II involved an active search for patients with Bordetella infections during a placebo-controlled trial of a pertussis toxoid vaccine.RESULTS: Study I includes 58, and study II 23 patients with parapertussis. In study I, the incidence of parapertussis was 0.016 cases per 100 person years in children 0 to 6 years old and 0 in older children and adults. In study II, the incidence rates of parapertussis and pertussis were 0.2 and 16.2 per 100 person years, respectively, in children followed from 3 months to 3 years of age. The median number of days with cough was 21 in parapertussis and 59 in pertussis. The proportions of children with whooping and vomiting were lower in parapertussis than in pertussis. Geometric mean serum filamentous hemagglutinin IgG increased from 6 to 63, and pertactin IgG from 4 to 12 units/mL in parapertussis patients, which was similar to increases in children with pertussis.CONCLUSIONS: Disease caused by Bordetella parapertussis is diagnosed less commonly and is milder and of shorter duration than disease caused by Bordetella pertussis. Parapertussis induced serum IgG against filamentous hemagglutinin and pertactin of similar magnitude as does pertussis, and did not induce serum IgG against pertussis toxin.