Zwitterionic character of nucleotides: possible significance in the evolution of nucleic acids.
Zwitterionic character of nucleotides: possible significance in the evolution of nucleic acids.
复制标题
核苷酸的两性离子特征：在核酸进化中的可能意义。
DOI：
10.1093/nar/5.11.4375
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发表时间：
1978
影响因子：
14.9
通讯作者：
P. Prusiner
中科院分区：
文献类型：
--
作者：
M. Sundaralingam;P. Prusiner
X射线晶体学表明，腺苷5 '-和3'-单磷酸以及胞苷5 '-和3'-单磷酸的游离酸在固态下以两性离子存在，其中腺嘌呤碱基在N（1）位点质子化，胞嘧啶碱基在相应的N（3）位点质子化，磷酸基团带负电荷。在本文中，证据提出的两性离子的性质的游离酸的单体核苷酸鸟苷5 '-单磷酸和肌苷5'-单磷酸与质子化的碱基在N（7）位的咪唑部分。
X-ray crystallography has shown that the free acids of adenosine 5'- and 3'-monophosphates and of cytidine 5'- and 3'-monophosphates exist as zwiterions in the solid state with protonation of the adenine base at the N(1) site and of the cytosine base at the corresponding site N(3) and the phosphate group negatively charged. In this paper, evidence is presented for the zwitterionic character of the free acids of the monomeric nucleotides guanosine 5'-monophosphate and inosine 5'-monophosphate with protonation of the base at the N(7) site of the imidazole moiety.