A Robust, “One-Pot” Method for Acquiring Kinetic Data for Hammett Plots Used To Demonstrate Transmission of Substituent Effects in Reactions of Aromatic Ethyl Esters
A Robust, “One-Pot” Method for Acquiring Kinetic Data for Hammett Plots Used To Demonstrate Transmission of Substituent Effects in Reactions of Aromatic Ethyl Esters
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一种稳健的“一锅法”方法，用于获取哈米特图的动力学数据，用于演示芳香族乙酯反应中取代基效应的传递
DOI：
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
J. Harper
中科院分区：
文献类型：
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作者：
H. M. Yau;R. Haines;J. Harper
本文介绍了一种用~（13）C核磁共振波谱法获得一系列取代芳香酯与氢氧化钾反应动力学数据的“一锅法”，它为在大学生实验室中获得足够的数据来证明Hammett方程提供了一种有效的方法。该方法是时间效率和鲁棒性，并适合于小组工作。该方法的高通量性质允许收集足够的数据，以探索具有不同链长的芳族部分和酯官能团之间的电子效应的传输。
A “one-pot” method for acquiring kinetic data for the reactions of a series of substituted aromatic esters with potassium hydroxide using 13C NMR spectroscopy is described, which provides an efficient way to obtain sufficient data to demonstrate the Hammett equation in undergraduate laboratories. The method is time-efficient and robust, and lends itself to group work. The high throughput nature of the method allows collection of sufficient data to explore the transmission of electronic effects between the aromatic moiety and the ester functionality with varying chain lengths.