A Multimodal Meta-Analysis of Structural and Functional Changes in the Brain of Tinnitus
A Multimodal Meta-Analysis of Structural and Functional Changes in the Brain of Tinnitus
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DOI：
10.3389/fnhum.2020.00028
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发表时间：
2020-02-25
影响因子：
2.9
通讯作者：
Liang, Fanrong
中科院分区：
文献类型：
--
作者：
Cheng, Shirui;Xu, Guixing;Liang, Fanrong
对耳鸣患者的脑成像研究揭示了大脑结构和功能的显着变化，但这些发现存在不一致之处。在这项荟萃分析中，我们调查了多项研究的一致性，以澄清耳鸣中大脑结构和功能的异常。在PubMed、Web of Science、EMBASE和科克伦图书馆数据库、中华民族知识基础设施、中国生物医学文献数据库、重庆VIP和万方数据库中检索了截至2019年12月6日发表的神经影像学研究。研究选择、质量评估和数据提取由两名独立的研究人员进行。使用各向异性效应大小符号差分映射（AES-SDM）对耳鸣患者报告全脑结构或功能数据的现有研究进行多模态分析。有14项研究符合纳入标准。结构数据集包括242名耳鸣患者和217名匹配的健康受试者（HS），而功能数据集包括130名耳鸣患者和140名匹配的HS。我们的分析揭示了上级颞回，颞中回（MTG），角回，尾状核，上级额回和辅助运动区的结构改变，以及MTG，枕中回，楔前叶和右顶下回（不包括缘上和角）的功能差异。多模态分析显示，耳鸣患者的右MTG相对于HS有显着差异。这些发现表明皮质-纹状体回路参与耳鸣的神经病理学。
Brain imaging studies of tinnitus patients have revealed marked changes in brain structure and function, but there are inconsistencies in those findings. In this meta-analysis, we investigated concurrence across studies to clarify those abnormalities in brain structure and function in tinnitus. Neuroimaging studies published up to December 6, 2019 were searched in the PubMed, Web of Science, EMBASE, and Cochrane Library databases, Chinese Nation Knowledge Infrastructure, Chinese Biomedical Literature Database, the Chongqing VIP, and Wanfang Database. Study selection, quality assessment, and data extraction were performed by two independent researchers. Anisotropic effect size signed differential mapping (AES-SDM) was used to perform a multimodal analysis of available studies reporting whole-brain structural or functional data in tinnitus patients. There were 14 studies that met the inclusion criteria. The structural dataset comprised 242 tinnitus patients and 217 matched healthy subjects (HS), while the functional dataset included 130 tinnitus patients and 140 matched HS. Our analysis revealed structural alterations in the superior temporal gyrus, middle temporal gyrus (MTG), angular gyrus, caudate nucleus, superior frontal gyrus, and supplementary motor area, as well as functional differences in the MTG, middle occipital gyrus, precuneus, and right inferior parietal (excluding supramarginal and angular) gyri. The multimodal analysis revealed significant differences in the right MTG of tinnitus patients relative to HS. These findings suggest the involvement of the cortico-striatal circuits in the neuropathology of tinnitus.