Angular velocity and head direction signals recorded from the dorsal tegmental nucleus of Gudden in the rat: Implications for path integration in the head direction cell circuit
Angular velocity and head direction signals recorded from the dorsal tegmental nucleus of Gudden in the rat: Implications for path integration in the head direction cell circuit
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DOI：
10.1037/0735-7044.115.3.571
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发表时间：
2001-06-01
影响因子：
1.9
通讯作者：
Cho, JW
中科院分区：
文献类型：
--
作者：
Sharp, PE;Tinkelman, A;Cho, JW
当老鼠在太空中航行时。头部方向（HD）细胞提供大鼠方向性前进的持续信号。据认为，这些细胞部分依赖于大鼠头部运动的角路径整合。这种集成要求HD单元系统接收关于头部角运动的信息，并且将该信息与当前方向信号组合，以产生下一个“预测”方向。最近的数据表明，背侧被盖核（DTN）可能在帮助产生HD细胞信号中发挥关键作用。为了验证这一点，记录了自由活动大鼠DTN中的细胞。发现了以下细胞类型：（a）“经典”HD细胞，（B）角速度细胞，以及（c）作为头部方向和角速度的函数而发射的细胞。因此，DTN细胞表现出放电特性，这对假设用于产生HD细胞信号的神经回路至关重要。
When a rat navigates through space. head direction (HD) cells provide an ongoing signal of the rat's directional heading, It is thought that these cells rely, in part, on angular path integration of the rat's head movements. This integration requires that the HD cell system receive information about angular head movements and that this information be combined with the current directional signal, to generate the next ''predicted" direction. Recent data suggest that the dorsal tegmental nucleus (DTN) may play a critical role in helping to generate the HD cell signal. To test this, recordings were made from cells in the DTN in freely moving rats. The following cell types were found: (a) "classic" HD cells, (b) angular velocity cells, and (c) cells that fired as a function of both head direction and angular velocity. Thus, DTN cells exhibit firing characteristics that are critical to the neural circuit hypothesized for generation of the HD cell signal.