Epigenetic regulation of cellular and cytomegalovirus genes during myeloid cell development.
Epigenetic regulation of cellular and cytomegalovirus genes during myeloid cell development.
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DOI：
10.18103/imr.v3i3.385
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发表时间：
2017-03
期刊：
影响因子：
--
通讯作者：
Abecassis M
中科院分区：
文献类型：
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作者：
Liu XF;Hummel M;Abecassis M
骨髓细胞是携带人巨细胞病毒的重要细胞类型。潜伏病毒DNA存在于CD34+祖细胞及其衍生的单核细胞中。然而，潜伏感染的单核细胞分化为成熟的巨噬细胞或树突状细胞导致潜伏病毒的再活化。在造血发育过程中，多能基因被抑制，谱系特异性基因以逐步的方式被激活。这一过程由细胞类型特异性染色质状态控制。造血系统中的增强子是高度动态的，并由先锋（第一层）转录因子（TF）建立，这为第二层和第三层TF结合奠定了基础。在这篇综述中，我们研究了表观遗传机制，调节骨髓细胞的发展，细胞的身份，并特别关注的因素，调节病毒基因表达和骨髓细胞中的病毒感染的状态激活。
Myeloid cells are important cell types that carry human cytomegalovirus. Latent viral DNA is present in CD34+ progenitor cells and their derived monocytes. However, differentiation of latently infected monocytes to mature macrophages or dendritic cells causes reactivation of latent viruses. During hematopoietic development, pluripotent genes are repressed, and lineage specific genes are activated in a step-wise manner. This process is governed by cell-type specific chromatin states. Enhancers in the hematopoietic system are highly dynamic and established by pioneer (first tier) transcription factors (TFs), which set the stage for second and third tier TF binding. In this review, we examine the epigenetic mechanisms that regulate myeloid cell development, cell identity, and activation with a special focus on factors that regulate viral gene expression and the status of viral infection in myeloid cells.