Metabolism of xylose by the lens, 2. Rat lens in vivo and in vitro.
Metabolism of xylose by the lens, 2. Rat lens in vivo and in vitro.
复制标题
晶状体对木糖的代谢，2.大鼠晶状体体内和体外。
DOI：
10.1042/bj0730197
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发表时间：
1959
影响因子：
4.1
通讯作者：
R. Heyningen
中科院分区：
文献类型：
--
作者：
R. Heyningen
当给断奶大鼠喂食含有35% d -木糖的饲料时，晶状体完全不透明（白内障）随之而来。相关文献已经在早期进行了总结（van Heyningen, 1958）。由于幼鼠晶状体非常小，幼鼠晶状体被用于晶状体体外代谢木糖的初步研究（van Heyningen, 1958）。本文研究了断奶大鼠晶状体对木糖的体内外代谢。白内障与喂食半乳糖或实验性糖尿病的白内障非常相似，在其最初阶段，并不是由于晶状体蛋白质的沉淀，而是由于晶状体最外层纤维的肿胀（von Sallmann, Caravaggio, Grimes & Collins, 1958; Friedenwald & Rytel, 1955）。
When a diet containing 35% of D-xylose is fed to a weanling rat, complete opacity of the lens (cataract) ensues. The relevant literature has been summarized earlier (van Heyningen, 1958). Because the young rat lens is very small, the calf lens was used for a preliminary investigation of the metabolism of xylose by the lens in vitro (van Heyningen, 1958). In the present work, the metabolism of xylose in vivo and in vitro by the lens of the weanling rat was investigated. The cataract, which closely resembles that due to feeding with galactose or experimental diabetes, does not appear in its initial stages to be due to precipitation of the proteins of the lens, but to swelling of the outermost lens fibres (von Sallmann, Caravaggio, Grimes & Collins, 1958; Friedenwald & Rytel, 1955).