Zebrafish hox clusters and vertebrate genome evolution
Zebrafish hox clusters and vertebrate genome evolution
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DOI：
10.1126/science.282.5394.1711
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发表时间：
1998-11-27
期刊：
影响因子：
56.9
通讯作者：
Postlethwait, JH
中科院分区：
文献类型：
--
作者：
Amores, A;Force, A;Postlethwait, JH
HOX基因在动物胚胎的前后轴中指定细胞命运。无脊椎脊索动物有一个HOX簇，但哺乳动物有四个，这表明簇复制促进了脊椎动物身体平面的进化。这份报告显示，斑马鱼有七个hox簇。系统发育分析和遗传作图表明，染色体加倍事件，可能是通过全基因组复制，后分歧的射线鳍和叶鳍鱼，但之前的硬骨鱼辐射。因此，硬骨鱼类，最丰富的脊椎动物群体，似乎有更多的副本;这些发育调控基因比哺乳动物，尽管在前-后轴的复杂性较低。
HOX genes specify cell fate in the anterior-posterior axis of animal embryos. Invertebrate chordates have one HOX cluster, but mammals have four, suggesting that cluster duplication facilitated the evolution of vertebrate body Plans. This report shows that zebrafish have seven hox clusters. Phylogenetic analysis and genetic mapping suggest a chromosome doubling event, probably by whole genome duplication, after the divergence of ray-finned and lobe-finned fishes but before the teleost radiation. Thus, teleosts, the most species-rich group of vertebrates, appear to have more copies of;these developmental regulatory genes than do mammals, despite Less complexity in the anterior-posterior axis.