Admixture into and within sub-Saharan Africa
Admixture into and within sub-Saharan Africa
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DOI：
10.7554/elife.15266
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发表时间：
2016-06-21
期刊：
影响因子：
7.7
通讯作者：
Spencer, Chris C. A.
中科院分区：
文献类型：
--
作者：
Busby, George B. J.;Band, Gavin;Spencer, Chris C. A.
两个个体之间在遗传标记沿着其染色体的组合中的相似性表明共同的祖先，并且可以用于识别由于混合而导致的不同群体之间的历史联系。我们使用全基因组，单倍型为基础的分析，以确定的遗传多样性和基因流的结构在48个撒哈拉以南非洲群体的集合。我们发现，沿海人口经历了欧亚单倍型在过去的7000年的涌入，东部和南部的刚果民主共和国讲群体的共同祖先与中西部非洲人作为最近的人口扩张的结果。事实上，由于过去4000年的基因流动，大多数撒哈拉以南的人口与来自其当前地理区域之外的群体共享祖先。我们的深入分析提供了深入了解不同民族语言群体之间的单倍型共享以及等位基因最近进入新环境的运动，这两者都与遗传流行病学研究有关。
Similarity between two individuals in the combination of genetic markers along their chromosomes indicates shared ancestry and can be used to identify historical connections between different population groups due to admixture. We use a genome-wide, haplotype-based, analysis to characterise the structure of genetic diversity and gene-flow in a collection of 48 sub-Saharan African groups. We show that coastal populations experienced an influx of Eurasian haplotypes over the last 7000 years, and that Eastern and Southern Niger-Congo speaking groups share ancestry with Central West Africans as a result of recent population expansions. In fact, most subSaharan populations share ancestry with groups from outside of their current geographic region as a result of gene-flow within the last 4000 years. Our in-depth analysis provides insight into haplotype sharing across different ethno-linguistic groups and the recent movement of alleles into new environments, both of which are relevant to studies of genetic epidemiology.