Effects of radiation on fatty liver and metabolic coronary risk factors among atomic bomb survivors in Nagasaki
Effects of radiation on fatty liver and metabolic coronary risk factors among atomic bomb survivors in Nagasaki
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DOI：
10.1291/hypres.26.965
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发表时间：
2003-12-01
影响因子：
5.4
通讯作者：
Yano, K
中科院分区：
文献类型：
--
作者：
Akahoshi, M;Amasaki, Y;Yano, K
为了阐明辐射暴露与冠心病（CHD）之间的基本机制，我们收集了1990年11月至1992年10月间1，517名长崎原子弹爆炸幸存者（男性575名，女性942名）的脂肪肝超声检查数据和代谢性CHD危险因素水平的测量结果。采用横断面研究设计，我们通过多元逻辑回归模型研究了辐射剂量对脂肪肝和冠心病危险因素的影响。脂肪肝与胰岛素抵抗综合征相关的代谢性CHD危险因素有关：肥胖、高血压、高胆固醇血症、低高密度脂蛋白（HDL）-胆固醇、高甘油三酯血症和糖代谢异常。辐射剂量与脂肪肝、低HDL-胆固醇和高胆固醇血症呈正相关，而对肥胖、高血压、高胆固醇血症或糖代谢异常无影响。目前的结果表明，辐射剂量与1）脂肪肝，聚集了与胰岛素抵抗综合征相关的代谢性CHD危险因素和2）致动脉粥样硬化脂质谱。提示这些关联参与了辐射暴露与冠心病之间的基本机制。
In order to clarify the basic mechanism(s) linking radiation exposure and coronary heart disease (CHD), we here collected ultrasonographic data on fatty liver and measured levels of metabolic CHD risk factors from November 1990 through October 1992 in 1,517 Nagasaki atomic bomb survivors (575 men and 942 women). Using a cross-sectional study design, we examined the effects of radiation dose on fatty liver and CHD risk factors by means of a multiple logistic regression model. Fatty liver was related to the metabolic CHD risk factors associated with insulin resistance syndrome: obesity, hypertension, hypercholesterolemia, low high density lipoprotein (HDL)-cholesterol, hypertriglyceridemia, and abnormal glucose metabolism. Radiation dose was positively related to fatty liver, low HDL-cholesterol, and hypertriglyceridemia, whereas it had no effects on obesity, hypertension, hypercholesterolemia, or abnormal glucose metabolism. The present results suggested that radiation dose was related to 1) fatty liver, which clustered the metabolic CHD risk factors associated with insulin resistance syndrome and 2) atherogenic lipid profiles. It is suggested that these associations are involved in the basic mechanism(s) linking radiation exposure and CHD.