L-arginine and Alzheimer's disease.
L-arginine and Alzheimer's disease.
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DOI：
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发表时间：
2009
影响因子：
1.4
通讯作者：
J. Yi;L. Horky;A. Friedlich;Ying Shi;J. Rogers;Xudong Huang
中科院分区：
文献类型：
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作者：
J. Yi;L. Horky;A. Friedlich;Ying Shi;J. Rogers;Xudong Huang
阿尔茨海默病（AD）是最常见的痴呆形式，其特征在于进行性神经变性以及认知和记忆功能的丧失。尽管AD的确切病因尚不清楚，但有证据表明动脉粥样硬化、氧化还原应激、炎症、神经递质失调和脑能量代谢受损都可能与AD的发病机制有关。在此，我们探讨了L-精氨酸（L-arg）在AD中的可能作用，考虑到已知的L-arg在动脉粥样硬化，氧化还原应激和炎症过程中的功能，突触可塑性和神经发生的调节，以及葡萄糖代谢和胰岛素活性的调节。L-arg是一氧化氮和多胺的前体，在人类健康中表现出多种功能，并且可能在与年龄相关的退行性疾病如AD中发挥重要作用。
Alzheimer's disease (AD), the most common form of dementia, is characterized by progressive neurodegeneration and loss of cognitive and memory functions. Although the exact causes of AD are still unclear, evidence suggests that atherosclerosis, redox stress, inflammation, neurotransmitter dysregulation, and impaired brain energy metabolism may all be associated with AD pathogenesis. Herein, we explore a possible role for L-arginine (L-arg) in AD, taking into consideration known functions for L-arg in atherosclerosis, redox stress and the inflammatory process, regulation of synaptic plasticity and neurogenesis, and modulation of glucose metabolism and insulin activity. L-arg, a precursor of nitric oxide and polyamine, exhibits multiple functions in human health and may play a prominent role in age-related degenerative diseases such as AD.