Cyclin D1, E2F1 expression levels are associated with characteristics and prognosis of esophageal squamous cell carcinoma
Cyclin D1, E2F1 expression levels are associated with characteristics and prognosis of esophageal squamous cell carcinoma
复制标题
DOI：
10.1111/j.1442-2050.2005.00463.x
复制
发表时间：
2005-01-01
影响因子：
2.6
通讯作者：
Kondo, S
中科院分区：
文献类型：
--
作者：
Mega, S;Miyamoto, M;Kondo, S
我们对食管鳞状细胞癌（ESCC）病例中E2 F1和细胞周期蛋白D1的表达进行了多机构分析。细胞周期蛋白D1和E2 F1参与细胞周期阶段的转变并与肿瘤进展相关。然而，没有以前的研究同时分析了E2 F1和细胞周期蛋白D1的表达。本研究旨在探讨E2 F1与cyclin D1在食管鳞癌中的关系。我们研究了122例接受手术切除肿瘤的原发性ESCC患者。对E2 F1和细胞周期蛋白D1进行免疫组织化学分析。统计分析免疫组化结果、临床病理特征和预后。31例患者（25.4%）存在E2 F1/细胞周期蛋白D1（-/-）肿瘤，与肿瘤进展减缓相关。在这些患者中，pT（P = 0.0001），pN（P < 0.0001），p-Stage（P = 0.0019）和生存率均优于E2 F1或cyclin D1阳性患者（P = 0.0232）。E2 F1和cyclin D1的表达是食管鳞癌患者肿瘤进展和预后的一个指标。联合检测E2 F1和cyclin D1的表达有助于判断食管鳞癌的临床特点和预后。
We performed a multi-institutional analysis of E2F1 and cyclin D1 expression in cases of esophageal squamous cell carcinoma (ESCC). Cyclin D1 and E2F1 are involved in the transition of cell cycle phases and associated with tumor progression. However, no previous studies have concurrently analyzed combined E2F1 and cyclin D1 expression. The purpose of this study was to clarify the relationship of E2F1 and cyclin D1 in ESCC. We studied 122 patients with primary ESCC who underwent surgical tumor resection. Immunohistochemical analyses were performed for E2F1 and cyclin D1. A statistical analysis of immunohistochemistry results, clinicopathological features, and prognosis was performed. E2F1/cyclin D1 (-/-) tumors were present in 31 patients (25.4%) and correlated with reduced tumor progression. In these patients, pT (P = 0.0001), pN (P < 0.0001), p-Stage (P = 0.0019), and survival rates were better than in patients who were positive for either E2F1 or cyclin D1 (P = 0.0232). The expression of E2F1 and cyclin D1 is an indicator of tumor progression and prognosis in patients with ESCC. Combined analysis of E2F1 and cyclin D1 expression helps to determine the characteristics and prognosis of ESCC.