Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors
Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors
复制标题
DOI：
10.1038/nm1521
复制
发表时间：
2007-01-01
期刊：
影响因子：
82.9
通讯作者：
Desreumaux, Pierre
中科院分区：
文献类型：
--
作者：
Rousseaux, Christel;Thuru, Xavier;Desreumaux, Pierre
腹痛在普通人群中很常见，肠易激综合征患者的腹痛归因于内脏过敏。我们发现，口服特定的乳杆菌菌株可诱导肠上皮细胞中μ阿片类药物和大麻素受体的表达，并介导肠道内的镇痛功能，类似于吗啡的作用。这些结果表明肠道微生物影响我们的内脏感知，并提出治疗腹痛和肠易激综合征的新方法。
Abdominal pain is common in the general population and, in patients with irritable bowel syndrome, is attributed to visceral hypersensitivity. We found that oral administration of specific Lactobacillus strains induced the expression of mu-opioid and cannabinoid receptors in intestinal epithelial cells, and mediated analgesic functions in the gut-similar to the effects of morphine. These results suggest that the microbiology of the intestinal tract influences our visceral perception, and suggest new approaches for the treament of abdominal pain and irritable bowel syndrome.