Neocortical lewy body counts correlate with dementia in the Lewy body variant of Alzheimer's disease.
Neocortical lewy body counts correlate with dementia in the Lewy body variant of Alzheimer's disease.
复制标题
新皮质路易体计数与阿尔茨海默病路易体变体的痴呆相关。
DOI：
10.1097/00005072-199601000-00005
复制
发表时间：
1996
影响因子：
3.2
通讯作者：
Hansen,LA
中科院分区：
文献类型：
--
作者：
Samuel,W;Galasko,D;Masliah,E;Hansen,LA
阿尔茨海默病(AD)的路易体变异(LBV)患者符合AD的诊断标准，但尽管有类似的痴呆，但AD斑块和错综复杂的AD病理负担较轻。我们使用抗泛素多克隆抗体对LBV患者(n=14)的新皮质路易小体进行了定量，选择了新皮质路易小体密度最高的区域进行定量。用硫代黄素-S检测新皮质神经原纤维缠结(NFT)和神经炎性斑块。一组病程匹配的典型AD患者(n=12)也被研究。对于这些病例中的大多数，先前已经通过应用Braak和Braak AD分期方案的修改来评估内嗅神经纤维病变。虽然LBV组和AD组在死亡前最后一次评估时有相似的智力测试分数，但LBV组观察到新皮质NFT和斑块计数较低，改良Braak分期较低。AD患者的新皮质NFT计数与神经心理测试成绩受损相关，而LBV患者则不相关。在任何一组中，斑块计数与精神状态都没有相关性。LBV患者四个新皮质区域的路易体浓度与痴呆严重程度显著相关。在LBV中，新皮质的AD损害与痴呆的关联比观察到的LBV浓度要弱得多。这些发现表明，新皮质脑白质瘤结合内嗅神经营养不良或皮质下帕金森病类型的病理可能使LBV中出现的痴呆程度与经典AD中遇到的程度相同。
Patients with the Lewy body variant (LBV) of Alzheimer's disease (AD) meet diagnostic criteria for AD but have a lighter burden of plaque and tangle AD pathology despite comparable dementia. We quantified neocortical Lewy bodies (LB) in LBV patients (n = 14) using anti-ubiquitin polyclonal antibody, selecting for quantification those neocortical regions with the highest densities of LB. Neocortical neurofibrillary tangles (NFT) and neuritic plaques were evaluated with thioflavin-S. A group of classical AD patients (n = 12), matched for disease duration, was also studied. For most of these cases, entorhinal neurofibrillary pathology had previously been assessed by applying a modification of the Braak and Braak AD staging protocol. Although LBV and AD groups had similar mental test scores when last evaluated prior to death, lower neocortical NFT and plaque counts and lower modified Braak stages were observed in LBV. Neocortical NFT counts correlated with impaired neuropsychological test performance in AD but not in LBV. Plaque counts did not correlate with mental status in either group. Lewy body concentrations in four neocortical areas correlated significantly with dementia severity in LBV. The association of AD lesions in the neocortex with dementia in LBV was comparatively weaker than that observed for LB concentrations. These findings suggest that neocortical LB combined with entorhinal NFT or subcortical Parkinson's disease-type pathology may equalize the degree of dementia seen in LBV with that encountered in classical AD.