EFFERENT PROJECTIONS OF THE PARAVENTRICULAR THALAMIC NUCLEUS IN THE RAT
EFFERENT PROJECTIONS OF THE PARAVENTRICULAR THALAMIC NUCLEUS IN THE RAT
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DOI：
10.1002/cne.903590204
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发表时间：
1995-08-21
影响因子：
2.5
通讯作者：
MOORE, RY
中科院分区：
文献类型：
--
作者：
MOGA, MM;WEIS, RP;MOORE, RY
丘脑室旁核（PVT）接收来自昼夜节律计时系统的所有主要组成部分的输入，包括视交叉上核（SCN），膝状体间叶和视网膜。为了更好地了解这个核在昼夜节律计时中的作用，我们使用顺行示踪剂菜豆白细胞凝集素（PHA-L）研究了其传出投射的分布。PVT的传出投射沿其背腹轴和前后轴沿着排列松散。前PVT将投射发送到SCN;下丘脑背内侧核和腹内侧核;外侧隔;终纹床核;中央杏仁核和基底内侧杏仁核;前嗅核;嗅结节;嗅核;边缘下、梨状和嗅周皮质;腹侧下托;和梨状内核。一个小PHA-L注射，仅限于前PVT的腹侧部分，产生类似的模式的标签，除了标记的纤维在下丘脑，皮质，和外侧隔的数量显着减少，并增加标记的内脊状核和基底外侧杏仁核。后PVT比前PVT具有更有限的传出分布，终止于前嗅核;嗅结节;延髓核;以及杏仁核的中央核、基底外侧核和基底内侧核。我们的研究结果表明，前PVT是理想的位置，从SCN的昼夜节律定时信息中继到大脑区域参与内脏和动机方面的行为，并提供反馈调节的SCN。(C)1995年Wiley-Liss，Inc.
The paraventricular nucleus of the thalamus (PVT) receives input from all major components of the circadian timing system, including the suprachiasmatic nucleus (SCN), the intergeniculate leaflet and the retina. For a better understanding of the role of this nucleus in circadian timing, we examined the distribution of its efferent projections using the anterograde tracer Phaseolus vulgaris leucoagglutinin (PHA-L). The efferent projections of the PVT are loosely organized along its dorsal-ventral and anterior-posterior axes. The anterior PVT sends projections to the SCN; the dorsomedial and ventromedial hypothalamic nuclei; the lateral septum; the bed nucleus of the stria terminalis; the central and basomedial amygdaloid nuclei; the anterior olfactory nucleus; the olfactory tubercle; the nucleus accumbens; the infralimbic, piriform, and perirhinal cortices; the ventral subiculum; and the endopiriform nucleus. A small PHA-L injection, restricted to the ventral portion of the anterior PVT, produces a similar pattern of labeling, except for a marked decrease in the number of labeled fibers in the hypothalamus, cortex, and lateral septum and an increase in labeling in the endopiriform nucleus and basolateral amygdaloid nucleus. The posterior PVT has a more limited efferent distribution than the anterior PVT, terminating in the anterior olfactory nucleus; the olfactory tubercle; the nucleus accumbens; and the central, basolateral, and basomedial nuclei of the amygdala. Our results show that the anterior PVT is ideally situated to relay circadian timing information from the SCN to brain areas involved in visceral and motivational aspects of behavior and to provide feedback regulation of the SCN. (C) 1995 Wiley-Liss, Inc.