GROWTH OF ALVEOLI AND PULMONARY ARTERIES IN CHILDHOOD
GROWTH OF ALVEOLI AND PULMONARY ARTERIES IN CHILDHOOD
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DOI：
10.1136/thx.25.6.669
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发表时间：
1970-01-01
期刊：
影响因子：
10
通讯作者：
REID, L
中科院分区：
文献类型：
--
作者：
DAVIES, G;REID, L
由于肺泡和气道的生长以前已经研究得比动脉生长更详细，本研究建立了动脉的生长模式，并将其与肺泡和airways.The出生后肺泡增殖的模式发现是相似的Dunnill报告，但所有年龄约10%以上，他的数字。肺泡大小在生命的前三、四年几乎没有变化，但此后稳步增加。肺泡形状的复杂性从4个月大开始增加。在动脉造影中，上叶的中央和外周动脉腔增加了4至5倍，下叶增加了3倍。显微镜检查显示，在4个月至3年之间，200 μm以下的动脉数量显著增加。每单位面积的肺组织中，5年后，这个数字福尔斯略有下降，可能反映了肺泡大小的增加。肌性、部分肌性和非肌性动脉在新生儿和成人相同大小范围内的分布相似。然而，在儿童时期，超过这个尺寸范围的动脉没有肌肉，而更大的动脉显示出这种混合的“群体”。11 ~ 19岁时，肌肉逐渐渗入腺泡形成成人型，肺动脉分支肌被厚度福尔斯在4月龄时降至成人水平。从出生到5岁，动脉的内侧面积在25到200 μm之间。单位面积肺的直径福尔斯下降，但11年后又上升了。
Since alveolar and airway growth have previously been studied in greater detail than has arterial growth, the present study establishes the growth pattern of the arteries and relates this to that of the alveoli and airways.The pattern of post-natal alveolar multiplication found is similar to that reported by Dunnill, but for all ages about 10% above his figure. Alveolar size hardly changes in the first three or four years of life but thereafter increases steadily. The complexity of alveolar shape increases from the age of 4 months.In arteriograms the arterial lumen, both centrally and peripherally, increases 4- to 5-fold in the upper lobe, 3-fold in the lower. Microscopic examination shows a striking increase between 4 months and 3 years in the number of arteries below 200 μm. per unit area of lung tissue; after 5 years this number falls slightly, probably reflecting an increase in alveolar size.Muscular, partially muscular and non-muscular arteries show a similar distribution over the same size range in the newborn as in the adult. During childhood, however, the arteries over this size range are free of muscle and much larger arteries show this mixed `population'. Between 11 and 19 years the adult pattern forms by progressive penetration of muscle into the acinus.The thickness of the muscle coat of pulmonary artery branches falls to adult levels by the age of 4 months. Between birth and 5 years the medial area of arteries between 25 and 200 μm. in diameter per unit area of lung falls, but has risen again by 11 years.