ELEVATED FIBRINOGEN AND PLASMINOGEN-ACTIVATOR INHIBITOR (PAI-1) IN HYPERTENSION ARE RELATED TO METABOLIC RISK-FACTORS FOR CARDIOVASCULAR-DISEASE
ELEVATED FIBRINOGEN AND PLASMINOGEN-ACTIVATOR INHIBITOR (PAI-1) IN HYPERTENSION ARE RELATED TO METABOLIC RISK-FACTORS FOR CARDIOVASCULAR-DISEASE
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DOI：
10.1111/j.1365-2796.1990.tb00157.x
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发表时间：
1990-04-01
影响因子：
11.1
通讯作者：
SMITH, U
中科院分区：
文献类型：
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作者：
LANDIN, K;TENGBORN, L;SMITH, U
在控制肥胖和脂肪组织分布(腰臀比)的情况下，研究高血压、糖代谢、纤维蛋白原与血管内皮细胞纤溶酶原激活物抑制物(PAI-1)的关系。22名血压正常的中年非肥胖男性(n=11)和未经治疗的轻度高血压(n=11)分别参与了这项研究。高血压男性的胆固醇、甘油三酯和胰岛素水平高于对照组。利用正常血糖钳夹技术研究了葡萄糖处理作为胰岛素敏感性的指标。在患有高血压的男性中，胰岛素效应往往不那么明显。高血压男性的PAI-1水平高于对照组。PAI-1与胰岛素水平呈显著正相关，血压、PAI-1及纤维蛋白原水平与葡萄糖代谢速率呈负相关。因此，即使在这些非肥胖和轻度高血压的个体中，也发现了心血管疾病代谢危险因素的增强。代谢异常与纤维蛋白原和PAI-1水平升高有关，后者反过来增加血栓形成的风险。
The relationship between hypertension, glucose metabolism, fibrinogen and plasminogen activator inhibitor of endothelial cell type (PAI-1) was studied under conditions in which the influence of obesity and adipose tissue distribution (waist/hip ratio) were controlled. Twenty-two non-obese, middle-aged men with normal blood pressure (n = 11) and untreated mild hypertension (n = 11), respectively, participated in the study. Cholesterol, triglyceride and insulin levels were higher in hypertensive men than in the control group. Glucose disposal was studied as an indicator of insulin sensitivity using the euglycaemic clamp technique. The insulin effect tended to be less marked in men with hypertension. PAI-1 was higher in hypertensive men compared to the controls. A strong positive correlation was observed between PAI-1 and insulin levels as well as blood pressure PAI-1 and fibrinogen levels correlated negatively with the rate of glucose disposal. Thus, even in these non-obese and mildly hypertensive individuals, an enhanced metabolic risk factor profile for cardiovascular disease was found. The metabolic aberrations were related to elevated fibrinogen and PAI-1 levels which, in turn, increase the risk of thrombus formation.