Aberrant expression of the growth factor Wnt-5A in human malignancy.
Aberrant expression of the growth factor Wnt-5A in human malignancy.
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发表时间：
1995-08
期刊：
影响因子：
11.2
通讯作者：
R. Iozzo;I. Eichstetter;K. Danielson
中科院分区：
文献类型：
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作者：
R. Iozzo;I. Eichstetter;K. Danielson
WNT-5A基因编码一种分泌的富含半胱氨酸的生长因子，在发育和个体发育过程中通过旁分泌机制介导细胞到细胞的信号传递。我们最近确定了人类WNT-5A的基因组组织和染色体图谱，并观察到在发育中的人类胚胎中不同的表达模式。在这份报告中，我们对100个成人组织和肿瘤以及10个人类细胞系进行了详细的表达分析。我们的数据显示WNT-5A在成人组织和细胞中广泛表达，在肺癌、乳腺癌、前列腺癌和黑色素瘤中表达异常。WNT-5A在人类恶性肿瘤中的上调既不是由于基因重排，也不是由于扩增。这些发现证明了这种生长因子在恶性肿瘤中的异常表达，并表明WNT-5A与人类癌症的发生有关。
The Wnt-5A gene codes for a secreted cysteine-rich growth factor that mediates cell to cell signaling via a paracrine mechanism during development and ontogeny. We have recently determine the genomic organization and chromosomal mapping of the human Wnt-5A, and observed distinct patterns of expression in developing human embryos. In this report, we have performed a detailed expression analysis of 100 adult human tissues and tumors and 10 human cell lines. Our data show a widespread expression of Wnt-5A in adult tissues and cells, and aberrant mRNA levels in lungs, breast, and prostate carcinomas and in melanomas. The up-regulation of Wnt-5A in human malignancy was not due to either gene rearrangement or amplification. These findings document an abnormal expression of this growth factor in malignancy and implicate Wnt-5A in the genesis of human cancer.