Modulation of Apolipoprotein D levels in human pregnancy and association with gestational weight gain
Modulation of Apolipoprotein D levels in human pregnancy and association with gestational weight gain
复制标题
DOI：
10.1186/1477-7827-7-92
复制
发表时间：
2009-09-02
影响因子：
4.4
通讯作者：
Rassart, Eric
中科院分区：
文献类型：
--
作者：
Do Carmo, Sonia;Forest, Jean-Claude;Rassart, Eric
工作背景：载脂蛋白D（ApoD）是一种脂质运载蛋白参与的几个过程，包括脂质运输，但其调制在人类pregnancy was never examined.Methods：我们调查了载脂蛋白D水平的变化在血浆中的孕妇在两个前三个月的妊娠和分娩，以及在胎盘和静脉脐带血。结果：151例正常无并发症妊娠妇女血浆ApoD水平明显下降，其中151例孕妇的血浆ApoD水平明显低于正常妊娠妇女，而151例孕妇的血浆ApoD水平明显低于正常妊娠妇女。ApoD在GWG过多的妇女及其新生儿中进一步降低。在这些女性中，ApoD浓度与血脂参数密切相关。然而，在低胆固醇（LC）和高胆固醇（HC）的妇女中的相似的ApoD水平表明，血浆ApoD的变化不是胆固醇依赖性的。胎盘ApoD转录和蛋白质含量的严格调节很可能是GWG过多女性循环ApoD浓度低的基础。分娩后，血浆ApoD浓度取决于母亲是否是母乳喂养或不，哺乳期有利于更快地返回到基线values.Conclusion：据推测，血浆ApoD浓度在怀孕期间的下降是一种适应性反应，旨在维持胎儿脂质稳态。这种适应的确切机制尚不清楚。
Background: Apolipoprotein D (ApoD) is a lipocalin involved in several processes including lipid transport, but its modulation during human pregnancy was never examined.Methods: We investigated the changes in the levels of ApoD in the plasma of pregnant women at the two first trimesters of gestation and at delivery as well as in the placenta and in venous cord blood. These changes were studied in 151 women classified into 9 groups in relation to their prepregnancy body mass index (BMI) and gestational weight gain (GWG).Results: Plasma ApoD levels decrease significantly during normal uncomplicated pregnancy. ApoD is further decreased in women with excessive GWG and their newborns. In these women, the ApoD concentration was tightly associated with the lipid parameters. However, the similar ApoD levels in low cholesterol (LC) and high cholesterol (HC) women suggest that the plasma ApoD variation is not cholesterol dependant. A tight regulation of both placental ApoD transcription and protein content is most probably at the basis of the low circulating ApoD concentrations in women with excessive GWG. After delivery, the plasma ApoD concentrations depended on whether the mother was breast-feeding or not, lactation favoring a faster return to baseline values.Conclusion: It is speculated that the decrease in plasma ApoD concentration during pregnancy is an adaptive response aimed at maintaining fetal lipid homeostasis. The exact mechanism of this adaptation is not known.