Anxiety and affective style: Role of prefrontal cortex and amygdala
Anxiety and affective style: Role of prefrontal cortex and amygdala
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DOI：
10.1016/s0006-3223(01)01328-2
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发表时间：
2002-01-01
影响因子：
10.6
通讯作者：
Davidson, RJ
中科院分区：
文献类型：
--
作者：
Davidson, RJ
本文回顾了情绪中枢回路的两个关键方面：前额叶皮层（PFC）和杏仁核的现代文献。PFC有几个不同的功能分区，包括背外侧区、腹内侧区和眶区。这些区域中的每一个都在情感处理中发挥着一定的作用，这些区域都具有在没有立即奖励和惩罚的情况下代表情感的特征，以及在情绪调节的不同方面。杏仁核似乎对学习新的刺激-威胁突发事件至关重要，在表达特定于线索的恐惧时也很重要。个体差异紧张性激活和阶段性反应在这一电路中发挥了重要作用，在管理不同方面的焦虑。重点放在情感测时法，或情绪反应的时间过程，作为个体差异的一个关键属性的倾向，焦虑是由这个电路调节。(C)2002生物精神病学学会。
This article reviews the modern literature on two key aspects of the central circuitry of emotion: the prefrontal cortex (PFC) and the amydala. There are several different functional divisions of the PFC, including the dorsolateral, ventromedial, and orbital sectors. Each of these regions plays some role in affective processing that shares the feature of representing affect in the absence of immediate rewards and punishments as well as in different aspects of emotional regulation. The amygdala appears to be crucial for the learning of new stimulus-threat contingencies and also appears to be important in the expression of cue-specific fear. Individual differences in both tonic activation and phasic reactivity in this circuit play an important role in governing different aspects of anxiety. Emphasis is placed on affective chronometry, or the time course of emotional responding, as a key attribute of individual differences in propensity, for anxiety that is regulated by this circuitry. (C) 2002 Society of Biological Psychiatry.